1. T lymphocyte receptor deficiencies.
- Author
-
Kappes DJ, Alarcón B, and Regueiro JR
- Subjects
- Amino Acid Sequence, Animals, Humans, Immunologic Deficiency Syndromes immunology, Molecular Sequence Data, Receptor-CD3 Complex, Antigen, T-Cell biosynthesis, Receptor-CD3 Complex, Antigen, T-Cell genetics, Immunologic Deficiency Syndromes genetics, Receptor-CD3 Complex, Antigen, T-Cell deficiency
- Abstract
Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules.
- Published
- 1995
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