1. The desmosome as a dynamic membrane domain.
- Author
-
Zimmer SE and Kowalczyk AP
- Subjects
- Humans, Animals, Endoplasmic Reticulum metabolism, Cell Adhesion, Adherens Junctions metabolism, Cell Membrane metabolism, Calcium metabolism, Desmosomes metabolism, Desmosomes chemistry
- Abstract
Cell junctions integrate extracellular signals with intracellular responses to polarize tissues, pattern organs, and maintain tissue architecture by promoting cell-cell adhesion and communication. In this review, we explore the mechanisms whereby the adhesive junctions, adherens junctions and desmosomes, co-assemble and then segregate into unique plasma membrane domains. In addition, we highlight emerging evidence that these junctions are spatially and functionally integrated with the endoplasmic reticulum to mediate stress sensing and calcium homeostasis. We conclude with a discussion of the role of the endoplasmic reticulum in the mechanical stress response and how disruption of these connections may cause disease., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
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