1. Javanicin, an antibacterial naphthaquinone from an endophytic fungus of neem, Chloridium sp.
- Author
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Kharwar RN, Verma VC, Kumar A, Gond SK, Harper JK, Hess WM, Lobkovosky E, Ma C, Ren Y, and Strobel GA
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents metabolism, Ascomycota chemistry, Ascomycota cytology, Ascomycota isolation & purification, Azadirachta physiology, Crystallography, X-Ray, Molecular Sequence Data, Naphthoquinones chemistry, Naphthoquinones isolation & purification, Naphthoquinones metabolism, Pseudomonas drug effects, Symbiosis, Anti-Bacterial Agents pharmacology, Ascomycota physiology, Azadirachta microbiology, Naphthoquinones pharmacology
- Abstract
The endophytic fungus Chloridium sp. produces javanicin under liquid and solid media culture conditions. This highly functionalized naphthaquinone exhibits strong antibacterial activity against Pseudomonas spp., representing pathogens to both humans and plants. The compound was crystallized and the structure was elucidated by X-ray crystallography. The X-ray structure confirms the previously elucidated structure of the compound that was done under standard spectroscopic methods. The importance of javanicin in establishing symbiosis between Chloridium sp. and its host plant, Azadirachta indica, is briefly discussed.
- Published
- 2009
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