1. Therapeutic Potential of Natural Psychoactive Drugs for Central Nervous System Disorders: A Perspective from Polypharmacology
- Author
-
Genís Ona and José Carlos Bouso
- Subjects
High interest ,Polypharmacology ,Central nervous system ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,Central Nervous System Diseases ,Drug Discovery ,Humans ,Medicine ,0101 mathematics ,030304 developmental biology ,Pharmacology ,Biological Products ,Psychotropic Drugs ,0303 health sciences ,biology ,business.industry ,Organic Chemistry ,Highly selective ,Ayahuasca ,biology.organism_classification ,010101 applied mathematics ,Safety profile ,medicine.anatomical_structure ,Drug development ,Molecular Medicine ,Cannabis ,business ,Neuroscience - Abstract
In the drug development, the formation of highly selective ligands has been unsuccessful in the treatment of central nervous system disorders. Multi-target ligands, from the polypharmacology paradigm, are being proposed as treatments for these complex disorders, since they offer enhanced efficacy and a strong safety profile. Natural products are the best examples of multi-target compounds, so they are of high interest within this paradigm. Additionally, recent research on psychoactive drugs of natural origin, such as ayahuasca and cannabis, has demonstrated the promising therapeutic potential for the treatment of some psychiatric and neurological disorders. In this text, we describe how research on psychoactive drugs can be effectively combined with the polypharmacology paradigm, providing ayahuasca and cannabis research as examples. The advantages and disadvantages are also discussed.
- Published
- 2020
- Full Text
- View/download PDF