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Start Over Author "Kaixiong Tao" Journal current medical science
6 results on '"Kaixiong Tao"'

4. Clinicopathological Characteristics and Prognosis of Hepatoid Adenocarcinoma of the Stomach: Evaluation of a Pooled Case Series

Author

Hua Xiao, Kaixiong Tao, Peng Zhang, Jun He, Jinbo Gao, Guobin Wang, Xiangyu Zeng, Xiaoming Shuai, Xiuli Wu, Weizhen Liu, and Yuping Yin

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Hepatoid adenocarcinoma, Adenocarcinoma, Biochemistry, Gastroenterology, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Internal medicine, Genetics, medicine, Adjuvant therapy, Humans, Gastric antrum, Neoadjuvant therapy, Retrospective Studies, business.industry, Stomach, Hazard ratio, Cancer, Middle Aged, medicine.disease, Prognosis, Confidence interval, Neoadjuvant Therapy, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Multivariate Analysis, 030211 gastroenterology & hepatology, Female, alpha-Fetoproteins, business
Abstract

Hepatoid adenocarcinoma of the stomach (HAS) is an extremely rare and unique gastric malignancy. The present study aimed to examine the relevance of the clinicopathological characteristics of HAS with patient prognosis. We retrospectively reviewed clinical data of 34 HAS patients treated at our institution between January 2010 and December 2016, as well as 294 cases reported prior to 2017 in research databases. Among these patients, 45.6% (115/252) had lesions in the gastric antrum and 77.0% (235/305) were male. Elevated levels of serum alpha-fetoprotein (AFP) were detected in most patients (75/93, 80.6%). Vascular invasion (199/286, 69.6%), lymph node metastasis (222/283, 78.4%), and preoperative distant metastasis (121/328, 36.9%) were commonly observed. The 5-year disease-free survival (DFS) and disease-specific survival (DSS) were 20.7% and 29.2%, respectively. DFS and DSS of patients receiving neoadjuvant therapy were significantly higher than those of patients receiving postoperative adjuvant therapy [DFS: P

Published
2018

6. Preparation of adriamycin magnetic albumin microspheres and their experimental antitumor effectsin vitroandin vivo

Author

Kaixiong, Tao, Daoda, Chen, Jianying, Chen, Yuan, Tian, Zaide, Wu, Xiansong, Wang, and Xiuping, Yang

Abstract

The adriamycin magnetic microspheres (ADM-MAMs) were prepared by the heat-stabilized protein methods. Their physico-chemical properties were examined; their cytotoxicities against tumor cellsin vitrowere assayed by a modified MTT method, and their effects were observed on the implanted gastric tumor in Wistar rats given ADM-MAMs via alimentary canal at the presence of the external magnetic fields. The results showed that the ADM-MAMs were successfully prepared and had cytotoxic effect on tumor cellsin vitrosimilar to the free ADM (P>0. 05). The inhibitory effects of ADM-MAMs on the implanted gastric tumorin vivowere significantly increased as compared with the controls (P<0. 01). Our results suggested that ADM-MAMs were a new type of adriamycin (ADM) preparation and its form alteration did not affect its anticancer effects.

Published
1999
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