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A review is offered to the articles "Switching from natalizumab to fingolimod in multiple sclerosis: a French prospective study" by M. Cohen and colleagues in the 2014 issue of the journal "JAMA Neurology," and "Fingolimod a fter natalizumab and the risk of short-term relapse."

A review is offered for the article "Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised Phase II trial" by T. Olsson and colleagues, published in the April 8, 2014 issue of the "Journal of Neurology Neurosurgery & Psychiatry."

A review is offered for the article "Fingolimod to treat severe multiple sclerosis after natalizumab-associated progressive multifocal leukoencephalopathy: a valid option?" by E. Maillart and colleagues, published in the 2014 issue of the "Multiple Sclerosis Journal."

An abstract of the article "Treatment of pediatric multiple sclerosis" by B. Kornek is presented.

An abstract of the article "Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis" by S. Al-Izki, G. Pryce and D. J. Hankey is presented.

An abstract of the article "Unique neuromyelitis optica pathology produced in naive rats by intracerebral administration of NMO-IgG" by N. Asavapanumas, J. Ratelade and A. S. Verkman is presented.

An abstract of the article "Resveratrol exacerbates both autoimmune and viral models of multiple sclerosis" by F. Sato, N. E. Martinez and colleagues is presented.

An abstract of the article "Immunotherapies influence the influenza vaccination response in multiple sclerosis patients: an explorative study" by H. K. Olberg, R. J. Cox and colleagues is presented.

An abstract of the article "Multiple sclerosis in the Iranian immigrant population of BC, Canada: prevalence and risk factors" by C. Guimond, J. D. Lee and colleagues is presented.

An abstract "Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions" by N. Muhlert, M. Atzori and colleagues is presented.

An abstract of the article "Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden" by H. Westerlind, R. Ramanujam and colleagues is presented.

An abstract of the article "Assessing treatment response to interferon -β : is there a role for MRI?" by R. Dobson, R. A. Rudick and colleagues is presented.

An abstract of the article "Vitamin D as an early predictor of multiple sclerosis activity and progression" by A. Ascherio, K. L. Munger and colleagues is presented.

An abstract of the article " Application of the 2012 revised diagnostic definitions for paediatric multiple sclerosis and immune-mediated central nervous system demyelination disorders" by E. D. van Pelt, R. F. Neuteboom and colleagues is presented.

An abstract of the article "Misdiagnosis of multiple sclerosis: frequency, causes, effects, and prevention" by A. J. Solomon and B. G. Weinshenker is presented.

An abstract of the article "Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration" by H. Kearney, M. A. Rocca and colleagues is presented.

An abstract of the article "Upper limb motor rehabilitation impacts white matter microstructure in multiple sclerosis" by L. Bonzano, A. Tacchino and colleagues is presented.

An abstract of the article "Temporal and spatial evolution of grey matter atrophy in primary progressive multiple sclerosis" by A. Eshaghi, B. Bodini and colleagues is presented.

An abstract of the article "Prolonged-release fampridine improves walking in a proportion of patients with multiple sclerosis" by H. K. Mathiesen and P. S. Sorensen is presented.

An abstract of the article "Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis" by L. Azzopardi, S. A. Thompson and colleagues is presented.

An abstract of the article "Comparative effectiveness of fingolimod versus interferons or glatiramer acetate for relapse rates in multiple sclerosis: a retrospective US claims database analysis" by N. Bergvall, C. Makin and colleagues is presented.

An abstract of the article "Risk acceptance in multiple sclerosis patients on natalizumab treatment" by C. Tur, M. Tintorée and colleagues is presented.

An abstract of the article "Randomized controlled trial of physical activity, cognition, and walking in multiple sclerosis" by B. M. Sandroff, R. E. Klaren and colleagues is presented.

An abstract of the article "Long-term impact of interferon beta-1b in patients with CIS: 8-year follow-up of BENEFIT" by G. Edan, L. Kappos and colleagues is presented.

An abstract of the article "Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis" by B. S. Chrabot, S.N. Kariuki and colleagues is presented.

An abstract of the article "Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis" by D. W. Hampton, A. Serio and colleagues is presented.

An abstract of the article "Synaptic plasticity in multiple sclerosis and in experimental autoimmune encephalomyelitis" by R. Nisticò, F. Mori and M. Feligioni is presented.

An abstract of the article "Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature" by G. V. Chaitanya, S. Omura and colleagues is presented.

The article presents a review of the study regarding the complications of interferon beta 1b treatment in patients with multiple sclerosis (MS). It provides details of the study that observes MS patients who have stopped taking natalizumab and switched to interferon-ß. It also outlines the result of the study which indicates both strength and limitations, and suggests for clinical and paraclinical recurrence of disease activity in patients who were given with natalizumab.

The article presents a review of the study regarding the diminishing B1-cell subpopulation in patients with relapsing-remitting multiple sclerosis (MS). It describes the method of the flow cytometry study that focused on B cell subsets and their role in relapsing forms of MS. It also mentions the result of the study which suggests further research on B cell phenotypes which could potentially contribute to more individualized MS therapy.

The article presents a review of the study regarding the assessment of clinical disease activities in patients with multiple sclerosis (MS). It chronicles the development of the MS Outcome Assessments Consortium (MSOAC) by the U.S. Food and Drug Administration (FDA) to develop reliable and meaningful clinician-reported outcome measures (ClinRO) to be used in clinical trials. It also mentions the workshop initiated by MSOAC to introduce tools that will determine disease activities in MS.

The article presents a review of the study concerning the effects of teriflunomide on the magnetic resonance imaging (MRI) surrogates of the disease activity in multiple sclerosis (MS). It provides details of the Phase III clinical trial of teriflunomide that involves 1088 patients with relapsing MS. It outlines the result of the study which confirms the beneficial effects of teriflunomide on MRI surrogates on the disease activity of MS.

The article presents a review of the study regarding the role of aquaporin-4 autoantibodies-immunoglobulin G (AQP4-IgG) as biomarkers for neuromyelitis optica (NMO). It describes the method of the study that observes AQP4-IgG rate for NMP patients through the use of contemporary recombinant antigen-based assays. It also mentions the findings of the study which suggests the need for additional study to standardize the serological testing used in diagnosing NMO.

The article presents a review on the study regarding the role of T cells homeostasis in pediatric patients with multiple sclerosis (MS). It describes the method of the study that observes 30 pediatric MS patients, 26 adults, and 67 age-matched controls. It recognizes the result of the study which was suggestive for age-corrected early thymic involution in pediatric patients with MS.

The article presents a review on the development of progressive multifocal leukeoncephalopathy (PML) in patients with multiple sclerosis (MS) treated with natalizumab. It details the method of the study which demonstrates how PML became apparent when the patient stopped the natalizumab treatment due to breast cancer diagnosis. It also recognizes the findings of the study which suggests that clinically silent phase might likely precede definitive signs of PML in patients with MS.

A review is offered for the article "JC virus in CD34+ and CD19+ cells in patients with multiple sclerosis treated with natalizumab" by E. M. Frohman, published in the 2014 issue of "JAMA Neurology."

A review is offered for the article "Cytomegalovirus seropositivity is negatively associated with multiple sclerosis" by E. Sundqvist, published in the "Multiple Sclerosis Journal."

A review is offered for the article "Catastrophic brain relapse in seronegative NMO after a single dose of natalizumab" by J. Kitiey and colleagues, published in the 2014 issue of the "Journal of the Neurological Sciences."

A review is offered for the article "Neuromyelitis optica spectrum disorders with aquaporin-4 and myelinoligodendrocyte glycoprotein antibodies: a comparative study" by J. Kitley and colleagues, published in the 2014 issue of the journal "JAMA Neurology."

A review of the article "Pathologic heterogeneity persists in early active multiple sclerosis lesions" by I. Metz, S. D. Weigand, B. F. Popescu, et al is presented, which was published in the 2014 issue of "Annals of Neurology."

An abstract of the article "Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of patients with multiple sclerosis" by T. Gabelic, D. P. Ramasamy and colleagues is presented.

An abstract of the article "Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case-control study" by A. L. Traboulsee, K. B. Knox and colleagues is presented.

An abstract of the article "Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent: results of a 5-year follow-up study" by O. Dolezal, T. Gabelic and colleagues is presented.

An abstract of the article "Patient-related factors may affect the outcome of neuropsychological rehabilitation in multiple sclerosis" by E. Rosti-Otajäarvi, A. Mantynen and colleagues is presented.

An abstract of the article "Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis" by N. Nathoo, V. W. Yong and J. F. Dunn is presented.

An abstract of the article "PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS" by D. Faria de Paula, E. F. de Vries and colleagues is presented.

An abstract of the article "Rituximab for relapsing-remitting multiple sclerosis" by D. He, R. Guo and colleagues is presented.

An abstract of the article "Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo controlled, Phase 3 trial" by C. Confavreux, P. O'Connor and colleagues is presented.

An abstract of the article "Assessment of cardiac safety during fingolimod treatment initiation in a real-world relapsing multiple sclerosis population: a Phase 3b, open-label study" by R. Gold, G. Comi and colleagues is presented.

An abstract of the article "A randomized clinical trial of oral versus intravenous methylprednisolone for relapse of MS" by C. Ramo-Tello, L. Grau-Lóopez and colleagues is presented.