1. CRISPR/Cas9-Mediated Immunity in Plants Against Pathogens
- Author
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Sameeullah, Muhammad, Khan, Faheem Ahmed, Gö, Ouml, ksel, zer, Aslam, Noreen, Gurel, Ekrem, Waheed, Mohammad Tahir, and Karadeniz, Turan
- Subjects
Crops, Agricultural ,0106 biological sciences ,0301 basic medicine ,Nematoda ,CRISPR/Cas9-Mediated ,Cyclopentanes ,Biology ,medicine.disease_cause ,01 natural sciences ,Genome ,03 medical and health sciences ,chemistry.chemical_compound ,Bacterial Proteins ,Plant Growth Regulators ,CRISPR-Associated Protein 9 ,medicine ,Animals ,CRISPR ,Oxylipins ,Pathogen ,Gene ,Disease Resistance ,Plant Diseases ,Plant Proteins ,Gene Editing ,Genetics ,Mutation ,Bacteria ,Cas9 ,Jasmonic acid ,fungi ,Fungi ,Immunity ,General Medicine ,Against ,Ethylenes ,Plants ,Endonucleases ,030104 developmental biology ,chemistry ,CRISPR-Cas Systems ,Pathogens ,Salicylic Acid ,Genome, Plant ,Salicylic acid ,010606 plant biology & botany - Abstract
Global crop production is highly threatened due to pathogen invasion. The huge quantity of pesticides application, although harmful to the environment and human health, is carried out to prevent the crop losses worldwide, every year. Therefore, understanding the molecular mechanisms of pathogenicity and plant resistance against pathogen is important. The resistance against pathogens is regulated by three important phytohormones viz. salicylic acid (SA), jasmonic acid (JA) and ethylene (ET). Here we review possible role of CRISPR technology to understand the plant pathogenicity by mutating genes responsible for pathogen invasion or up-regulating the phytohormones genes or resistant genes. Thus hormone biosynthesis genes, receptor and feeding genes of pathogens could be important targets for modifications using CRISPR/Cas9 following multiplexing tool box strategy in order to edit multiple genes simultaneously to produce super plants. Here we put forward our idea thatthe genes would be either mutated in case of plant receptor protein targets of pathogens or up-regulation of resistant genes or hormone biosynthesis genes will be better choice for resistance against pathogens.
- Published
- 2017
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