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Your search keyword '"conditioned odor aversion"' showing total 2 results
Start Over Descriptor "conditioned odor aversion" Journal current biology
2 results on '"conditioned odor aversion"'

1. CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory

Author

Nagore Puente, Geoffrey Terral, Pedro Grandes, Svein Achicallende, Luigi Bellocchio, Arnau Busquets-Garcia, Guillaume Ferreira, Giovanni Marsicano, Marjorie Varilh, Itziar Bonilla-Del Río, Federico Massa, Astrid Cannich, Edgar Soria-Gomez, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB), University of the Basque Country, Achucarro Basque Center for Neuroscience, Ikerbasque - Basque Foundation for Science, Nutrition et Neurobiologie intégrée (NutriNeuro), and Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique

Subjects
0301 basic medicine, Olfactory system, Male, neuroanatomy, [SDV]Life Sciences [q-bio], Piriform Cortex, Biology, Inhibitory postsynaptic potential, General Biochemistry, Genetics and Molecular Biology, conditioned odor aversion, 03 medical and health sciences, Mice, 0302 clinical medicine, Receptor, Cannabinoid, CB1, Memory, Piriform cortex, miniature inhibitory currents, semilunar neurons, Animals, anterior piriform cortex, mIPSCs, Olfactory memory, Receptor, pyramidal neurons, [SDV.GEN]Life Sciences [q-bio]/Genetics, musculoskeletal, neural, and ocular physiology, Olfactory Perception, Smell, Electrophysiology, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, 030104 developmental biology, Odor, nervous system, Odorants, GABAergic, lipids (amino acids, peptides, and proteins), General Agricultural and Biological Sciences, Neuroscience, conditioned odor preference, CB1 receptors, 030217 neurology & neurosurgery, psychological phenomena and processes
Abstract

International audience; The retrieval of odor-related memories shapes animal behavior. The anterior piriform cortex (aPC) is the largest part of the olfactory cortex, and it plays important roles in olfactory processing and memory. However, it is still unclear whether specific cellular mechanisms in the aPC control olfactory memory, depending on the appetitive or aversive nature of the stimuli involved. Cannabinoid-type 1 (CB1) receptors are present in the aPC (aPC-CB1), but their potential impact on olfactory memory was never explored. Here, we used a combination of behavioral, genetic, anatomical, and electrophysiological approaches to characterize the functions of aPC-CB1 receptors in the regulation of appetitive and aversive olfactory memory. Pharmacological blockade or genetic deletion of aPC-CB1 receptors specifically impaired the retrieval of conditioned odor preference (COP). Interestingly, expression of conditioned odor aversion (COA) was unaffected by local CB1 receptor blockade, indicating that the role of aPC endocannabinoid signaling is selective for retrieval of appetitive memory. Anatomical investigations revealed that CB1 receptors are highly expressed on aPC GABAergic interneurons, and ex vivo electrophysiological recordings showed that their pharmacological activation reduces miniature inhibitory post-synaptic currents (mIPSCs) onto aPC semilunar (SL), but not pyramidal principal neurons. COP retrieval, but not COA, was associated with a specific CB1-receptor-dependent decrease of mIPSCs in SL cells. Altogether, these data indicate that aPC-CB1 receptor-dependent mechanisms physiologically control the retrieval of olfactory memory, depending on odor valence and engaging modulation of local inhibitory transmission.

Published
2019
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2. CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory.

Author

Terral, Geoffrey, Busquets-Garcia, Arnau, Varilh, Marjorie, Achicallende, Svein, Cannich, Astrid, Bellocchio, Luigi, Bonilla-Del Río, Itziar, Massa, Federico, Puente, Nagore, Soria-Gomez, Edgar, Grandes, Pedro, Ferreira, Guillaume, and Marsicano, Giovanni

Subjects
*INTERNEURONS, *PYRAMIDAL neurons, *CELLULAR control mechanisms, *ODORS, *ANIMAL behavior, *AVERSIVE stimuli, *MEMORY
Abstract

The retrieval of odor-related memories shapes animal behavior. The anterior piriform cortex (aPC) is the largest part of the olfactory cortex, and it plays important roles in olfactory processing and memory. However, it is still unclear whether specific cellular mechanisms in the aPC control olfactory memory, depending on the appetitive or aversive nature of the stimuli involved. Cannabinoid-type 1 (CB1) receptors are present in the aPC (aPC-CB1), but their potential impact on olfactory memory was never explored. Here, we used a combination of behavioral, genetic, anatomical, and electrophysiological approaches to characterize the functions of aPC-CB1 receptors in the regulation of appetitive and aversive olfactory memory. Pharmacological blockade or genetic deletion of aPC-CB1 receptors specifically impaired the retrieval of conditioned odor preference (COP). Interestingly, expression of conditioned odor aversion (COA) was unaffected by local CB1 receptor blockade, indicating that the role of aPC endocannabinoid signaling is selective for retrieval of appetitive memory. Anatomical investigations revealed that CB1 receptors are highly expressed on aPC GABAergic interneurons, and ex vivo electrophysiological recordings showed that their pharmacological activation reduces miniature inhibitory post-synaptic currents (mIPSCs) onto aPC semilunar (SL), but not pyramidal principal neurons. COP retrieval, but not COA, was associated with a specific CB1-receptor-dependent decrease of mIPSCs in SL cells. Altogether, these data indicate that aPC-CB1 receptor-dependent mechanisms physiologically control the retrieval of olfactory memory, depending on odor valence and engaging modulation of local inhibitory transmission. • CB1 receptors are highly expressed in anterior piriform cortex (aPC) interneurons • aPC-CB1 receptors control retrieval of conditioned odor preference (COP) • aPC-CB1 receptors are not involved in retrieval of conditioned odor aversion • COP retrieval is linked to CB1-dependent reduction of aPC inhibitory transmission Terral et al. explore the role of the endocannabinoid system in olfactory memory functions. They show that cannabinoid type-1 (CB1) receptors control the retrieval of appetitive, but not aversive, olfactory memory, associated with a modulation of local inhibitory transmission onto specific principal neurons of the anterior piriform cortex. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
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