2 results on '"Anna Linderholm"'
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2. Natural and human-driven selection of a single non-coding body size variant in ancient and modern canids
- Author
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Jocelyn Plassais, Bridgett M. vonHoldt, Heidi G. Parker, Alberto Carmagnini, Nicolas Dubos, Ilenia Papa, Kevin Bevant, Thomas Derrien, Lauren M. Hennelly, D. Thad Whitaker, Alex C. Harris, Andrew N. Hogan, Heather J. Huson, Victor F. Zaibert, Anna Linderholm, James Haile, Thierry Fest, Bilal Habib, Benjamin N. Sacks, Norbert Benecke, Alan K. Outram, Mikhail V. Sablin, Mietje Germonpré, Greger Larson, Laurent Frantz, Elaine A. Ostrander, National Human Genome Research Institute (NHGRI), Princeton University, Queen Mary University of London (QMUL), Territoires, Environnement, Télédétection et Information Spatiale (UMR TETIS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer (MOBIDIC), Université de Rennes (UR)-Etablissement français du sang [Rennes] (EFS Bretagne)-Institut National de la Santé et de la Recherche Médicale (INSERM), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Sud [CHU Rennes], CHU Pontchaillou [Rennes], Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Eugène Marquis (CRLCC), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California [Davis] (UC Davis), University of California (UC), Cornell University [New York], Al-Farabi Kazakh National University [Almaty] (KazNU), Stockholm University, University of Oxford, German Archaeological Institute (DAI), University of Exeter, Zoological Institute of Russian Academy of Sciences, Russian Academy of Sciences [Moscow] (RAS), Royal Belgian Institute of Natural Sciences (RBINS), Ludwig Maximilian University [Munich] (LMU), Intramural Program of the National Human Genome Research Institute (J.P., H.G.P., A.N.H., and E.A.O.). J.P. is also funded by Region Bretagne and Ligue Contre le Cancer. B.M.v.H. is funded by Princeton University. L.F., J.H., and G.L. were supported by the ERC (grant ERC-2013-StG-337574-UNDEAD and ERC-2019-StG-853272-PALAEOFARM) and Natural Environment Research Council grants (NE/K005243/1 and NE/K003259/1). L.F. and A.C. were supported by the Wellcome Trust (210119/Z/18/Z). B.H.’s research was funded by DST, the Government of India, and Maharashtra Forest Department., and Jonchère, Laurent
- Subjects
canine ,[SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics ,Breeding ,canid evolution ,Medical and Health Sciences ,Article ,General Biochemistry, Genetics and Molecular Biology ,domestication ,wolf ,[SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,Genetics ,Animals ,Humans ,Body Size ,ancient DNA ,Alleles ,Canidae ,Wolves ,long non-coding RNA ,[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,IGF1 ,Psychology and Cognitive Sciences ,Biological Sciences ,[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics ,dog ,antisense lncRNA ,body size ,General Agricultural and Biological Sciences ,Developmental Biology - Abstract
Domestic dogs (Canis lupus familiaris) are the most variable-sized mammalian species on Earth displaying a 40-fold size difference between breeds(1). Although dogs of variable size are found in the archeological record(2–4), the most dramatic shifts in body size are the result of selection over the last two centuries, as dog breeders selected and propagated phenotypic extremes within closed breeding populations(5). Analyses of over 200 domestic breeds have identified approximately 20 body size genes regulating insulin processing, fatty acid metabolism, TGFβ signaling and skeletal formation(6–10). Of these, Insulin-like Growth Factor 1 (IGF1) predominates, controlling approximately 15% of body size variation between breeds(8). The identification of a functional mutation associated with IGF1 has thus far proven elusive(6,10,11). Here, to identify and elucidate the role of an ancestral IGF1 allele in the propagation of modern canids, we analyzed 1,431 genome sequences from 13 species, including both ancient and modern canids, thus allowing us to define the evolutionary history of both ancestral and derived alleles at this locus. We identified a single variant in an antisense long non-coding RNA (IGF1-AS) that interacts with the insulin-like growth factor-1 (IGF1) gene creating a duplex. While the derived mutation predominates in both modern grey wolves and large domestic breeds, the ancestral allele, which predisposes to small size, was common in small-sized breeds and smaller wild canids. Our analyses demonstrate that this major regulator of canid body size nearly vanished in Pleistocene wolves, before its recent resurgence resulting from human-imposed selection for small-sized breed dogs.
- Published
- 2022
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