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The dietary intake of omega-3 (n-3) polyunsaturated fatty acids has emerged, over the past 20 years, as an important way to modify cardiovascular risk. This likely occurs through beneficial effects at all stages in the natural history of vascular disease, from the inception of atherosclerotic lesions, to their growth and acute complications (plaque rupture in most instances), up to protection of myocardium from the consequences of ensuing acute myocardial ischemia. This review specifically focuses on the modulating effects of n-3 fatty acids on biologic events involved in early atherogenesis, including important properties of these natural substances on endothelial expression of adhesion molecules and cytokines, processes collectively denoted as “endothelial activation.” By decreasing the endothelial responsiveness to proinflammatory and proatherogenic stimuli, n-3 fatty acids act on molecular events not targeted by any other drugs or interventions, and thereby complementary to those of already implemented pharmacologic treatments. [ABSTRACT FROM AUTHOR]

Endothelial-leukocyte adhesion molecules are involved in processes regulating the selective attachment of leukocytes to the vessel wall, which participate in tissue inflammation, atherogenesis, and immunity. There has been recent appreciation that diet or specific dietary components may modulate such processes. Highly unsaturated— particularly omega-3 — fatty acids and antioxidants are receiving increasing attention in this regard as potential antiatherogenic and anti-inflammatory agents. The vascular surface expression of endothelial leukocyte molecules can also be reflected by plasma levels of “soluble” adhesion molecules, thus allowing the assessment of the effects of diet and selected dietary components on these processes in vivo. [ABSTRACT FROM AUTHOR]