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Posteromedial Instability Syndrome of the Elbow (PMIE) is a condition that arises from injuries to the stabilizing structures of the elbow joint, such as the coronoid process or ulnar lateral collateral ligament. Surgical treatment is commonly performed, but there is uncertainty regarding its results. This systematic review will synthesise the available evidence regarding the efficacy of surgical approaches to PMIE. Published and unpublished primary studies that regard outcomes of patients treated for PMIE, irrespective of approach, will be considered for inclusion. Iterative searches will be performed in the PubMed/MEDLINE, EMBASE, and Cochrane CENTRAL repositories from their inception to May 2023. Grey literature repositories will also be searched. The Cochrane risk of bias tool will be used to assess the quality of eligible interventional studies, while the MINORS tool will be employed for observational studies. If possible, a meta-analysis based on the random-effects model will be conducted. Heterogeneity will be assessed using Cochrane's Q and I 2 statistics, and explored through subgroup analyses and sensitivity analyses. Relevant outcomes will include elbow joint functionality as assessed by validated scales, the proportion of patients returning to usual daily life activities, the development of recurrent joint instability in the postoperative period, quality of life and the development of postoperative arthritis. This protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO) at the University of York. Its registration number is CRD42023451516., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Moreno-Castillo et al.)