1. Past and Future of the Molecular Characterization of the T Cell Repertoire: Some Highlights of Eli Sercarz's Contributions.
- Author
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Di Sante G, Tredicine M, Rolla S, Di Pino A, and Ria F
- Subjects
- Allergy and Immunology history, Allergy and Immunology trends, Animals, Autoimmune Diseases diagnosis, Autoimmune Diseases genetics, Autoimmune Diseases immunology, High-Throughput Nucleotide Sequencing, History, 20th Century, Humans, Immunophenotyping history, Immunophenotyping trends, Neoplasms diagnosis, Neoplasms genetics, Neoplasms immunology, Polymorphism, Genetic, Receptors, Antigen, T-Cell metabolism, T-Lymphocytes metabolism, V(D)J Recombination, Genes, T-Cell Receptor genetics, Immunophenotyping methods, Receptors, Antigen, T-Cell genetics, T-Lymphocytes immunology
- Abstract
The contribution of Eli E. Sercarz to immunology and immunopathology has been remarkable and achieved many milestones in the understanding of the processes of the mechanisms fine-tuning immune responses. A part of his work was dedicated to the study of the deep complexity of the lymphocyte T cell repertoire and its importance during the physiologic development and disease, such as clonal heterogeneity of T cell responses. Starting from these studies, under his mentoring, we had the opportunity to implement the spectratyping method and apply it to human and experimental autoimmune diseases, obtaining intriguing results. The open question of this brief review is the possible role of this fine and complex technique, the immunoscope analysis, in the era of the big data and omics.
- Published
- 2020
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