1. Protein synthesis and degradation during development
- Author
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S. M. Russell, Mayer Rj, Colin J. Wilde, R. J. Burgess, and Patrick A. Sinnett-Smith
- Subjects
Monoamine oxidase ,Adipose tissue ,Biology ,Organ culture ,Ammonium Chloride ,Mammary Glands, Animal ,Organ Culture Techniques ,Pregnancy ,Protein biosynthesis ,Cytochrome c oxidase ,Animals ,Lactation ,Protein turnover ,Caseins ,Proteins ,General Medicine ,Pyruvate dehydrogenase complex ,Hormones ,Cytosol ,Kinetics ,Biochemistry ,Adipose Tissue ,Liver ,biology.protein ,RNA ,Female ,Fatty Acid Synthases ,Lysosomes ,Half-Life ,Subcellular Fractions - Abstract
The degree of coordination between protein synthesis and degradation during protein accretion or diminution in three different types of development transition is examined. Protein turnover patterns in postnatally developing liver, terminally differentiating mammary gland, and in maternal adipose tissue in the perinatal period are presented. Studies on turnover of specific enzymes and resolved protein populations from morphologically (biosynthetically) defined organelle subcompartments are presented. Data are given on the turnover characteristics of monoamine oxidase, pyruvate dehydrogenase, and cytochrome oxidase, as well as proteins in defined mitochondrial subcompartments from rat liver. The turnover characteristics of fatty acid synthetase, casein, and cytosol proteins in rabbit mammary explants in organ culture arc presented. Changes in turnover characteristics of lipogenic enzymes, mitochondrial proteins, and cytosol proteins in maternal rat subcutaneous and parametrial adipose tissue around parturit...
- Published
- 1982