1. Acute lung inflammatory response and injury after hemorrhagic shock are more severe in postpartum rabbits
- Author
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Chen hong Wang, Liping Huang, Robert F Lodato, Ke-seng Zhao, Ding Sheng Zha, Chao Sheng, Y.H. Yu, Zhijian Wang, and Sui Hai Wang
- Subjects
Resuscitation ,medicine.medical_specialty ,Acute Lung Injury ,Lung injury ,Shock, Hemorrhagic ,Critical Care and Intensive Care Medicine ,Interstitial fluid ,Pregnancy ,medicine ,Animals ,Prospective cohort study ,Lung ,Peroxidase ,business.industry ,Tumor Necrosis Factor-alpha ,Postpartum Period ,NF-kappa B ,Pneumonia ,medicine.disease ,Intercellular Adhesion Molecule-1 ,Surgery ,Interleukin-10 ,Disease Models, Animal ,medicine.anatomical_structure ,Anesthesia ,Shock (circulatory) ,Tumor necrosis factor alpha ,Female ,Rabbits ,medicine.symptom ,business - Abstract
OBJECTIVE The acute respiratory distress syndrome may complicate postpartum hemorrhagic shock and resuscitation, but its mechanisms are not yet well defined. We studied the lung inflammatory response to postpartum hemorrhagic shock and resuscitation in a rabbit model and the role of the nuclear factor-κB pathway. DESIGN Randomized, controlled, prospective study. SETTING University hospital laboratory. SUBJECTS Nonobstetric (not pregnant nor postpartum) and obstetrical (within 2 hrs postpartum) rabbits. INTERVENTIONS Nonobstetric and obstetric female New Zealand white rabbits underwent fixed-pressure or fixed-volume hemorrhagic shock for 30 mins and then were rapidly resuscitated with the shed blood and Ringer's solution. Finally, they were either monitored for survival time or euthanized by exsanguination for lung tissue examination 24 hrs after hemorrhage. MEASUREMENTS AND MAIN RESULTS After hemorrhagic shock and resuscitation, median survival time in obstetric rabbits (3 days) was significantly shorter (p
- Published
- 2012