1. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)
- Author
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Andrew Rhodes, Michael S. Aboodi, Eddy Fan, Waleed Alhazzani, Jill S. Morgan, Massimiliano Greco, Paul E. Alexander, Amy L. Dzierba, Lennie P. G. Derde, Mark Loeb, Maurizio Cecconi, Kathryn Maitland, Amy S. Arrington, Leonard A. Mermel, Bandar Baw, Daniel S. Chertow, Simon Oczkowski, John Centofanti, Ziad A. Memish, Michelle Ng Gong, Manoj J. Mammen, Laura Evans, Younsuck Koh, Yaseen M. Arabi, Hannah Wunsch, Bin Du, Naomi E Hammond, Frederick G Hayden, Matthew Laundy, Allison McGeer, Giuseppe Citerio, Morten Hylander Møller, Jozef Kesecioglu, Emilie P. Belley-Côté, Fayez Alshamsi, Mitchell M. Levy, Alhazzani, W, Møller, M, Arabi, Y, Loeb, M, Gong, M, Fan, E, Oczkowski, S, Levy, M, Derde, L, Dzierba, A, Du, B, Aboodi, M, Wunsch, H, Cecconi, M, Koh, Y, Chertow, D, Maitland, K, Alshamsi, F, Belley-Cote, E, Greco, M, Laundy, M, Morgan, J, Kesecioglu, J, Mcgeer, A, Mermel, L, Mammen, M, Alexander, P, Arrington, A, Centofanti, J, Citerio, G, Baw, B, Memish, Z, Hammond, N, Hayden, F, Evans, L, and Rhodes, A
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medicine.medical_specialty ,Surviving Sepsis Campaign ,Best practice ,Coronaviru ,MEDLINE ,SARS CoV-2 ,1110 Nursing ,Critical Care and Intensive Care Medicine ,1117 Public Health and Health Services ,Special Article ,03 medical and health sciences ,0302 clinical medicine ,Health care ,Pandemic ,medicine ,Infection control ,Critical illne ,Grading (education) ,Intensive care medicine ,Clinical practice guideline ,business.industry ,Conflict of interest ,COVID-19 ,1103 Clinical Sciences ,030208 emergency & critical care medicine ,Emergency & Critical Care Medicine ,Coronavirus ,COVID-19 guideline ,Systematic review ,030228 respiratory system ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Clinical practice guidelines ,Critical illness ,business - Abstract
Supplemental Digital Content is available in the text., Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed. Methods: We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations. Results: The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which four are best practice statements, nine are strong recommendations, and 35 are weak recommendations. No recommendation was provided for six questions. The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy. Conclusion: The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new evidence in further releases of these guidelines.
- Published
- 2020
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