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3 results on '"Maddalena Peghin"'

1. Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

Author

Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Cecilia Trucchi, Filippo Ansaldi, Massimo Antonelli, Vaclava Adamkova, Cristiano Alicino, Maria-Panagiota Almyroudi, Enora Atchade, Anna M. Azzini, Novella Carannante, Alessia Carnelutti, Silvia Corcione, Andrea Cortegiani, George Dimopoulos, Simon Dubler, José L. García-Garmendia, Massimo Girardis, Oliver A. Cornely, Stefano Ianniruberto, Bart Jan Kullberg, Katrien Lagrou, Clement Le Bihan, Roberto Luzzati, Manu L. N. G. Malbrain, Maria Merelli, Ana J. Marques, Ignacio Martin-Loeches, Alessio Mesini, José-Artur Paiva, Maddalena Peghin, Santi Maurizio Raineri, Riina Rautemaa-Richardson, Jeroen Schouten, Pierluigi Brugnaro, Herbert Spapen, Polychronis Tasioudis, Jean-François Timsit, Valentino Tisa, Mario Tumbarello, Charlotte H. S. B. van den Berg, Benoit Veber, Mario Venditti, Guillaume Voiriot, Joost Wauters, and Philippe Montravers

Subjects
ICU, Candidemia, Candidiasis, Candida, Abdominal candidiasis, Incidence, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p

Published
2019
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2. Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

Author

Herbert D. Spapen, Massimo Girardis, Polychronis Tasioudis, Santi Maurizio Raineri, Jose Luis Garcia-Garmendia, Philippe Montravers, Valentino Tisa, Alessio Mesini, Massimo Antonelli, Novella Carannante, Stefano Ianniruberto, Jean-François Timsit, Mario Venditti, Filippo Ansaldi, Joost Wauters, Mario Tumbarello, Cecilia Trucchi, Matteo Bassetti, Manu L N G Malbrain, Katrien Lagrou, Silvia Corcione, Enora Atchade, Bart Jan Kullberg, Alessia Carnelutti, Cristiano Alicino, Pierluigi Brugnaro, José Artur Paiva, Riina Rautemaa-Richardson, Ana J Marques, Maria-Panagiota Almyroudi, George Dimopoulos, Clément Le Bihan, Andrea Cortegiani, Maria Merelli, Anna Maria Azzini, Simon Dubler, Daniele Roberto Giacobbe, Charlotte H S B van den Berg, Maddalena Peghin, Benoit Veber, Jeroen Schouten, Roberto Luzzati, Antonio Vena, Guillaume Voiriot, Oliver A. Cornely, Vaclava Adamkova, Ignacio Martin-Loeches, Bassetti M., Giacobbe D.R., Vena A., Trucchi C., Ansaldi F., Antonelli M., Adamkova V., Alicino C., Almyroudi M.-P., Atchade E., Azzini A.M., Carannante N., Carnelutti A., Corcione S., Cortegiani A., Dimopoulos G., Dubler S., Garcia-Garmendia J.L., Girardis M., Cornely O.A., Ianniruberto S., Kullberg B.J., Lagrou K., Le Bihan C., Luzzati R., Malbrain M.L.N.G., Merelli M., Marques A.J., Martin-Loeches I., Mesini A., Paiva J.-A., Peghin M., Raineri S.M., Rautemaa-Richardson R., Schouten J., Brugnaro P., Spapen H., Tasioudis P., Timsit J.-F., Tisa V., Tumbarello M., Van Den Berg C.H.S.B., Veber B., Venditti M., Voiriot G., Wauters J., Montravers P., Bassetti, M., Giacobbe, D. R., Vena, A., Trucchi, C., Ansaldi, F., Antonelli, M., Adamkova, V., Alicino, C., Almyroudi, M. -P., Atchade, E., Azzini, A. M., Carannante, N., Carnelutti, A., Corcione, S., Cortegiani, A., Dimopoulos, G., Dubler, S., Garcia-Garmendia, J. L., Girardis, M., Cornely, O. A., Ianniruberto, S., Kullberg, B. J., Lagrou, K., Le Bihan, C., Luzzati, R., Malbrain, M. L. N. G., Merelli, M., Marques, A. J., Martin-Loeches, I., Mesini, A., Paiva, J. -A., Peghin, M., Raineri, S. M., Rautemaa-Richardson, R., Schouten, J., Brugnaro, P., Spapen, H., Tasioudis, P., Timsit, J. -F., Tisa, V., Tumbarello, M., Van Den Berg, C. H. S. B., Veber, B., Venditti, M., Voiriot, G., Wauters, J., Montravers, P., Faculty of Psychology and Educational Sciences, Supporting clinical sciences, Intensive Care, and Internal Medicine Specializations

Subjects
Male, Outcome Assessment, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], MULTICENTER, Critical Care and Intensive Care Medicine, law.invention, 610 Medical sciences Medicine, 0302 clinical medicine, Retrospective Studie, Risk Factors, law, Outcome Assessment, Health Care, EPIDEMIOLOGY, Medicine, Cumulative incidence, PREDICTORS, Candida, Medicine(all), Cross Infection, Incidence, Incidence (epidemiology), lcsh:Medical emergencies. Critical care. Intensive care. First aid, Candidiasis, Middle Aged, Intensive care unit, Europe, Intensive Care Units, Abdominal candidiasis, Candidemia, ICU, Aged, Candidiasis, Invasive, Female, Humans, Retrospective Studies, Candidiasi, SOFA score, Life Sciences & Biomedicine, Human, medicine.medical_specialty, Invasive, Intensive Care Unit, Abdominal candidiasis, Candida, Candidemia, Candidiasis, ICU, Incidence, 03 medical and health sciences, Critical Care Medicine, General & Internal Medicine, Intensive care, Settore MED/41 - ANESTESIOLOGIA, MANAGEMENT, Science & Technology, business.industry, Septic shock, INTRAABDOMINAL CANDIDIASIS, Research, 030208 emergency & critical care medicine, Retrospective cohort study, lcsh:RC86-88.9, Odds ratio, medicine.disease, Health Care, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Emergency medicine, Abdominal candidiasi, business
Abstract

Contains fulltext : 206779.pdf (Publisher’s version ) (Open Access) BACKGROUND: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. METHODS: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). RESULTS: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. CONCLUSIONS: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

Published
2019
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3. Is first-line antimicrobial therapy still adequate to treat MRSA in the ICU? A report from a highly endemic country

Author

Enrico Maria Tricarichi, Matteo Bassetti, Maddalena Peghin, Paola Del Giacomo, Alessia Carnelutti, Cecilia Trucchi, Filippo Ansaldi, Cristiano Alicino, Mario Tumbarello, and Elda Righi

Subjects
Male, Methicillin-Resistant Staphylococcus aureus, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Letter, medicine.medical_treatment, 030106 microbiology, MRSA, Settore MED/17 - MALATTIE INFETTIVE, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Intensive care, Internal medicine, Odds Ratio, medicine, Humans, Endocarditis, Infection control, 030212 general & internal medicine, Aged, Retrospective Studies, Cross Infection, business.industry, Septic shock, Retrospective cohort study, Odds ratio, Middle Aged, Staphylococcal Infections, medicine.disease, Confidence interval, Anti-Bacterial Agents, Intensive Care Units, Logistic Models, Italy, ICU, Female, business, MRSA, ICU, Central venous catheter
Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infections cause great concern in intensive care units (ICUs) [1]. Although strict infection control protocols have reduced staphylococcal colonization, the ICU still represents a reservoir for MRSA infections, playing a role in their circulation to multiple wards and hospitals [2–4]. In critically ill patients, lack of adequate treatment may lead to increased mortality [1]. For this reason, broad-spectrum antimicrobial therapy is often justified among critically ill patients. We retrospectively analyzed the characteristics of S. aureus bloodstream infections (SA-BSI) from two Italian University hospitals during 2010–2014. A total of 17/337 (5 %) were ICU patients; of these, 16 (94 %) had MRSA-BSI compared with 36 % (116/320) from other wards (P

Published
2016
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