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Your search keyword '"Gerie J. Glas"' showing total 2 results
Start Over Author "Gerie J. Glas" Journal critical care
2 results on '"Gerie J. Glas"'

1. Nebulized heparin for patients under mechanical ventilation: a conventional data meta-analysis

Author

Janneke Horn, Ary Serpa Neto, MJ Schultz, and Gerie J. Glas

Subjects
Mechanical ventilation, medicine.medical_specialty, Critically ill, business.industry, medicine.medical_treatment, Heparin, Critical Care and Intensive Care Medicine, medicine.disease, Meta-analysis, Anesthesia, Poster Presentation, medicine, Coagulopathy, Intensive care medicine, business, medicine.drug
Abstract

Mechanical ventilation has the potential to induce pulmonary coagulopathy. Local treatment by nebulization of heparin could be beneficial in ventilated patients. The aim of this data metaanalysis is to determine the association between nebulization of heparin and outcome of mechanically ventilated critically ill patients.

Published
2015
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2. Nebulized Cl-esterase inhibitor treatment does not attenuate pulmonary complement activation in a rat model of severe Streptococcus pneumoniae pneumonia

Author

Gerie J. Glas, Charlotte J. P. Beurskens, FM de Beer, Janneke Horn, MJ Schultz, and Wim K. Lagrand

Subjects
Pathology, medicine.medical_specialty, Lung, business.industry, Rat model, Inflammation, respiratory system, Lung injury, Critical Care and Intensive Care Medicine, respiratory tract diseases, Complement system, Streptococcus pneumoniae pneumonia, Pathogenesis, medicine.anatomical_structure, Immunology, Poster Presentation, medicine, medicine.symptom, Esterase inhibitor, business
Abstract

While complement protein deficiencies are associated with severe and recurrent pulmonary infections, excessive complement activation plays a role in the pathogenesis of lung injury. We hypothesized that inhibition of the complement system by repetitive treatment with nebulized plasma-derived human C1-esterase inhibitor (C1-INH) reduces pulmonary complement activation and subsequently attenuates lung injury and lung inflammation in a model of severe Streptococcus pneumoniae pneumonia.

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