1. Acute coronary syndromes in patients with HIV.
- Author
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Seecheran VK, Giddings SL, and Seecheran NA
- Subjects
- Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome mortality, Acute Coronary Syndrome therapy, Anti-HIV Agents adverse effects, Antiretroviral Therapy, Highly Active, Early Diagnosis, HIV Infections diagnosis, HIV Infections epidemiology, Humans, Life Expectancy, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Acute Coronary Syndrome epidemiology, Anti-HIV Agents therapeutic use, HIV Infections drug therapy
- Abstract
Highly active antiretroviral treatment (HAART) has considerably increased the life expectancy of patients infected with HIV. Coronary artery disease is a leading cause of mortality in patients infected with HIV. This is primarily attributed to their increased survival, HAART-induced metabolic derangements, and to HIV itself. The pathophysiology of atherosclerosis in HIV is both multifactorial and complex - involving direct endothelial injury and dysfunction, hypercoagulability, and a significant contribution from traditional cardiac risk factors. The advent of HAART has since heralded a remarkable improvement in outcomes, but at the expense of other unforeseen issues. It is thus of paramount importance to swiftly recognize and manage acute coronary syndromes in HIV-infected patients to attenuate adverse complications, which should translate into improved clinical outcomes.
- Published
- 2017
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