1. Biodegradable polymer drug-eluting stents versus durable polymer drug-eluting stents for percutaneous coronary intervention: a contemporary registry-based analysis
- Author
-
Tamir Bental, Yeela Talmor-Barkan, Guy Witberg, Abed Samara, Leor Perl, Pablo Codner, Amos Levi, Aharon Erez, Uri Landes, Gabriel Greenberg, Hanna Vaknin-Assa, Mark Kheifets, and Ran Kornowski
- Subjects
Drug ,Target lesion ,Male ,medicine.medical_specialty ,media_common.quotation_subject ,medicine.medical_treatment ,Percutaneous Coronary Intervention ,Durable polymer ,Absorbable Implants ,medicine ,Humans ,Durable Medical Equipment ,Myocardial infarction ,Registries ,Propensity Score ,media_common ,Aged ,business.industry ,Percutaneous coronary intervention ,Drug-Eluting Stents ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,Propensity score matching ,Cohort ,Conventional PCI ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims We aimed to compare the long-term outcomes of patients undergoing percutaneous coronary intervention (PCI) with biodegradable polymer drug-eluting stents (BP-DES) versus durable polymer drug-eluting stents (DP-DES). Methods and results Among 11 517 PCIs with second-generation DES performed in our institution between 2007 and 2019, we identified 8042 procedures performed using DP-DES and 3475 using BP-DES. The primary outcome was target lesion failure, the composite target lesion revascularization (TLR), target vessel myocardial infarction and death. Propensity score matching was used to create a well-balanced cohort. Mean follow-up was 4.8 years. Of the 3413 matched pairs, 21% were females, and the mean age was 66 years. At 1 year, the primary outcome occurred in 8.3% patients versus 7.1% (P = 0.07), and TLR rate was 3% versus 2% (P = 0.006) in patients with DP-DES and BP-DES respectively. Within 5 years, the primary outcome occurred in 23.1% versus 23.4% (P = 0.44), and the rate of TLR was 7.2% versus 6.5% (P = 0.07) in patients with DP-DES and BP-DES, respectively. Conclusion Similar rates of the composite outcome were observed throughout the entire follow-up. target vessel revascularization rates were lower in the DP-DES group at 1 year but equalized within 5 years.
- Published
- 2021