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3. Association Between Fuchs Endothelial Corneal Dystrophy, Diabetes Mellitus, and Multimorbidity

Author

Nealon, Cari L., Halladay, Christopher W., Gorman, Bryan R., Simpson, Piana, Roncone, David P., Canania, Rachael L., Anthony, Scott A., Sawicki Rogers, Lea R., Leber, Jenna N., Dougherty, Jacquelyn M., Cooke Bailey, Jessica N., Crawford, Dana C., Sullivan, Jack M., Galor, Anat, Wu, Wen-Chih, Greenberg, Paul B., Lass, Jonathan H., Iyengar, Sudha K., and Peachey, Neal S.

Published
2023
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6. Corneal Graft Rejection 10 Years After Penetrating Keratoplasty in the Cornea Donor Study

Author

Dunn, Steven P, Gal, Robin L, Kollman, Craig, Raghinaru, Dan, Dontchev, Mariya, Blanton, Christopher L, Holland, Edward J, Lass, Jonathan H, Kenyon, Kenneth R, Mannis, Mark J, Mian, Shahzad I, Rapuano, Christopher J, Stark, Walter J, and Beck, Roy W

Subjects
Organ Transplantation, Eye Disease and Disorders of Vision, Neurodegenerative, Clinical Research, Transplantation, Rare Diseases, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Eye, Aged, Allografts, Corneal Edema, Follow-Up Studies, Fuchs' Endothelial Dystrophy, Graft Rejection, Graft Survival, Humans, Incidence, Keratoplasty, Penetrating, Middle Aged, Postoperative Complications, Risk Factors, Tissue Donors, Transplant Recipients, corneal graft rejection, penetrating keratoplasty, corneal graft failure, Writing Committee for the Cornea Donor Study Research Group, Clinical Sciences, Opthalmology and Optometry, Ophthalmology & Optometry
Abstract

PurposeThe aim of this study was to assess the effect of donor and recipient factors on corneal allograft rejection and evaluate whether a rejection event was associated with graft failure.MethodsOne thousand ninety subjects undergoing penetrating keratoplasty for a moderate risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) were followed for up to 12 years. Associations of baseline recipient and donor factors with the occurrence of a rejection event were assessed in univariate and multivariate proportional hazards models.ResultsAmong 651 eyes with a surviving graft at 5 years, the 10-year graft failure (±99% confidence interval) rates were 12% ± 4% among eyes with no rejection events in the first 5 years, 17% ± 12% in eyes with at least 1 probable, but no definite rejection event, and 22% ± 20% in eyes with at least 1 definite rejection event. The only baseline factor significantly associated with a higher risk of definite graft rejection was a preoperative history of glaucoma, particularly when previous glaucoma surgery had been performed and glaucoma medications were being used at the time of transplant (10-year incidence 35% ± 23% compared with 14% ± 4% in eyes with no history of glaucoma/intraocular pressure treatment, P = 0.008).ConclusionsPatients who experienced a definite rejection event frequently developed graft failure raising important questions as to how we might change acute and long-term corneal graft management. Multivariate analysis indicated that previous use of glaucoma medications and glaucoma filtering surgery was a significant risk factor related to a definite rejection event.

Published
2014

7. Prelamellar Dissection Donor Corneal Thickness Is Associated With Descemet Stripping Automated Endothelial Keratoplasty Operative Complications in the Cornea Preservation Time Study

Author

Ross, Kevin W., Stoeger, Christopher G., Rosenwasser, George O. D., OʼBrien, Robert C., Szczotka-Flynn, Loretta B., Ayala, Allison R., Maguire, Maureen G., Benetz, Beth Ann, Dahl, Patricia, Drury, Donna C., Dunn, Steven P., Farazdaghi, Sameera M., Hoover, Caroline K., Macsai, Marian S., Mian, Shahzad I., Nordlund, Michael L., Penta, Jeffrey G., Soper, Mark C., Terry, Mark A., Verdier, David D., Williams, Doyce V., and Lass, Jonathan H.

Published
2019
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15. Contributors

Author

Abbott, Richard L, primary, Adrean, Sean D, additional, Al-Muammar, Abdulrahman, additional, Akhtar, Jihan, additional, Alfonso, Eduardo C, additional, Allen, Richard C, additional, Almond, M Camille, additional, Alvarenga, Lênio, additional, Alward, Wallace LM, additional, Ambrósio, Renato, additional, Anwar, Mohammad, additional, Azar, Dimitri T, additional, Ball, James L, additional, Barney, Neal P, additional, Bartow, Rebecca M, additional, Baum, Jules, additional, Belin, Michael W, additional, Bell, Jason H, additional, Benetz, Beth Ann, additional, Berbos, Zachary, additional, Beuerman, Roger W, additional, Bhasin, Arpita Kadakia, additional, Bhat, Pooja V, additional, Biber, Joseph M, additional, Bidros, Maria, additional, Birnbaum, Andrea D, additional, Bouchard, Charles S, additional, Bradley, Jay C, additional, Brandt, James D, additional, Brasington, Richard D, additional, Brilakis, Harilaos S, additional, Burkat, Cat N, additional, Calatayud, Marta, additional, Cameron, J Douglas, additional, Campos, Mauro, additional, Carpel, Emmett F, additional, Cavanagh, H Dwight, additional, Chan, Cordelia, additional, Chang, Richard I, additional, Chang, Bernard H, additional, Chern, Kenneth C, additional, Ching, Steven, additional, Chodosh, James, additional, Choo, Phillip H, additional, Chung, Gary, additional, Ciolino, Joseph B, additional, Clayton, Janine A, additional, Cohen, Elisabeth J, additional, Comyn, Oliver, additional, Cortina, M Soledad, additional, Cowden, John W, additional, Croasdale, Christopher R, additional, Davidson, Richard S, additional, Davis, Elizabeth A, additional, Daya, Sheraz M, additional, Freitas, Denise de, additional, DeMill, David L, additional, de Oliveira, Lauro Augusto, additional, de Smet, Marc D, additional, de Sousa, Luciene B, additional, Djalilian, Ali R, additional, Dohlman, Claes H, additional, Donnenfeld, Eric D, additional, Dortzbach, Richard K, additional, Driebe, William T, additional, Dunn, Steven P, additional, Eagle, Ralph C, additional, Edelstein, Sean L, additional, Eiferman, Richard A, additional, Eliason, Joseph A, additional, Farid, Marjan, additional, Faulkner, William J, additional, Feder, Robert S, additional, Feiz, Vahid, additional, Feng, Matthew T, additional, Fingert, John H, additional, Florakis, George J, additional, Fontana, Luigi, additional, Forster, Richard K, additional, Foster, C Stephen, additional, Foster, F Stuart, additional, Foulks, Gary N, additional, Friedlander, Mitchell H, additional, Fukuda, Masahiko, additional, Galor, Anat, additional, Gan, Theresa J, additional, Garg, Prashant, additional, Garg, Sumit, additional, Glasser, David B, additional, Goins, Kenneth M, additional, Goldstein, Debra A, additional, Gottlieb, Chloe, additional, Grimmett, Michael R, additional, Gris, Oscar, additional, Groos, Erich B, additional, Gruzensky, William D, additional, Güell, Jose L, additional, Gupta, Preeya K, additional, Hamill, M Bowes, additional, Hammersmith, Kristin M, additional, Hamrah, Pedram, additional, Hannush, Sadeer B, additional, Hardten, David R, additional, Harrison, Andrew, additional, Heck, Ellen L, additional, Heidemann, David G, additional, Herman, David C, additional, Heur, J Martin, additional, Hodge, William G, additional, Hoffman, Carol J, additional, Holland, Edward J, additional, Holland, Gary N, additional, Honig, Marc A, additional, Hood, Christopher T, additional, Hoskins, Eliza N, additional, Huang, Andrew J W, additional, Huang, David, additional, Hui, Jennifer I, additional, Iuorno, Joseph D, additional, Jackson, W Bruce, additional, Jakobiec, Frederick A, additional, Jeng, Bennie H, additional, Jester, James V, additional, Jordan, David R, additional, Kaiura, Terry L, additional, Karp, Carol L, additional, Katz, Douglas G, additional, Kaufman, Stephen C, additional, Kersten, Robert C, additional, Khachikian, Stephen S, additional, Kim, Jennifer H, additional, Kim, Joung Y, additional, Kim, Stella K, additional, Kim, Terry, additional, Kirkness, Colin M, additional, Klyce, Stephen D, additional, Koch, Douglas D, additional, Kowalski, Regis P, additional, Krachmer, Jay H, additional, Laibson, Peter R, additional, Lane, Stephen S, additional, Lass, Jonathan H, additional, Lee, W Barry, additional, Lee, Olivia A, additional, Lemp, Michael A, additional, Lenhart, Phoebe D, additional, Li, Yan, additional, Liesegang, Thomas J, additional, Lim, Michele C, additional, Lin, Lily Koo, additional, Lin, Michael P, additional, Lindquist, Thomas D, additional, Lindstrom, Richard L, additional, Litoff, David, additional, Liu, Christopher, additional, Lowder, Careen Y, additional, Lubniewski, Anthony J, additional, McGee, Hall T, additional, McLean, Ian W, additional, Macsai, Marian S, additional, Manero, Felicidad, additional, Mannis, Mark J, additional, Mantopoulos, Dimosthenis, additional, Martinez, Carlos E, additional, Mártonyi, Csaba L, additional, Mashor, Raneen S, additional, Mathers, William D, additional, Mehta, Manisha N, additional, Meisler, David M, additional, Mian, Shahzad I, additional, Miller, Darlene, additional, Miller, Corey A, additional, Montoya, Monty, additional, Morral, Merce, additional, Moyes, Andrew L, additional, Murphy, Michael L, additional, Nassiri, Nariman, additional, Neff, Kristiana D, additional, Nelson, J Daniel, additional, Nerad, Jeffrey A, additional, Netto, Marcelo V, additional, Newton, Christopher J, additional, Nijm, Lisa M, additional, Nishida, Teruo, additional, Noble, Bruce A, additional, Nordlund, Michael L, additional, Nussenblatt, Robert B, additional, O'Day, David G, additional, Ongkosuwito, Jenny V, additional, Oxford, Karen W, additional, Palay, David A, additional, Palmon, Florentino E, additional, Paranjpe, Deval R, additional, Parikh, Mansi, additional, Park, David H, additional, Park, D J John, additional, Parsons, Matthew R, additional, Pavlin, Charles J, additional, Pearlstein, Eric S, additional, Perry, Alicia, additional, Petroll, W Matthew, additional, Pfister, Daryl R, additional, Pfister, Roswell R, additional, Pflugfelder, Stephen C, additional, Price, Francis W, additional, Price, Marianne O, additional, Probst, Louis E, additional, Purcell, John J, additional, Pyott, Andrew A E, additional, Raizman, Michael B, additional, Raju, Leela V, additional, Randleman, J Bradley, additional, Rao, Gullapalli N, additional, Rapuano, Christopher J, additional, Reilly, Charles D, additional, de Candelaria Renesto, Adimara, additional, Rezende, Renata A, additional, Robertson, Danielle M, additional, Rootman, David S, additional, Rothman, Jason S, additional, Rubinfeld, Roy Scott, additional, Sadowsky, Alan E, additional, Saika, Shizuya, additional, Sakhalkar, Monali V, additional, Salz, James J, additional, Sangwan, Virender S, additional, Scarpi, Marinho, additional, Scharf, Bradley H, additional, Schmidt, Greg, additional, Schmitt, Artur, additional, Schmitt, Fernanda Piccoli, additional, Schteingart, Miriam T, additional, Schwab, Ivan R, additional, Schwam, Brian L, additional, Schwartz, Gary S, additional, Sen, H Nida, additional, Shapiro, Michael B, additional, Shimmura, Shigeto, additional, Singal, Neera, additional, Skeens, Heather M, additional, Skolnick, Craig A, additional, Slomovic, Allan R, additional, Smith, Janine A, additional, Snyder, Michael E, additional, Solomon, Renée, additional, Soukiasian, Sarkis H, additional, Srinivasan, Sathish, additional, Stamler, John F, additional, Steinert, Roger F, additional, Stoller, Glenn L, additional, Streeten, Barbara W, additional, Stulting, R Doyle, additional, Sugar, Alan, additional, Sugar, Joel, additional, Tan, Donald, additional, Tauber, Joseph, additional, Terry, Mark A, additional, Tessler, Howard H, additional, Torrabadella, Marta, additional, Traboulsi, Elias I, additional, Trattler, William B, additional, Tsai, Julie H, additional, Tse, David T, additional, Tu, Elmer Y, additional, Ursea, Roxana, additional, Vaddavalli, Pravin K, additional, Van Meter, Woodford S, additional, Varley, Gary A, additional, Vasaiwala, Roshni, additional, Verachtert, Anthony J, additional, Verdier, David D, additional, Vieira, Ana Carolina, additional, Virasch, Vanee V, additional, Wang, Li, additional, Waring, George O, additional, Warner, Michael A, additional, Warrian, Kevin J, additional, Webster, Guy F, additional, Weikert, Mitchell P, additional, Weisenthal, Robert W, additional, Weiss, Jayne S, additional, Wichiensin, Pongmas, additional, Wilhelmus, Kirk R, additional, Wilson, Steven E, additional, Woodward, Maria A, additional, Yee, Richard W, additional, and Yoo, Sonya, additional

Published
2011
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17. Effects of Repeated Intravitreal Aflibercept Injection on the Corneal Endothelium in Patients With Age-Related Macular Degeneration: Outcomes From the RE-VIEW Study

Author

Lass, Jonathan H., primary, Benetz, Beth Ann, additional, Menegay, Harry J., additional, Tsipis, Constantinos P., additional, Cook, Jane Caty, additional, Boyer, David S., additional, Singer, Michael, additional, Erickson, Kristine, additional, Saroj, Namrata, additional, Vitti, Robert, additional, Chu, Karen W., additional, Moini, Hadi, additional, Soo, Yuhwen, additional, and Cheng, Yenchieh, additional

Published
2018
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18. Validity of Postmortem Glycated Hemoglobin to Determine Status of Diabetes Mellitus in Corneal Donors

Author

Soper, Mark C., primary, Marcovina, Santica M., additional, Hoover, Caroline K., additional, Calhoun, Peter M., additional, McCoy, Kristen E., additional, Stoeger, Christopher G., additional, Schmidt, Gregory A., additional, Arafah, Baha M., additional, Price, Marianne O., additional, Szczotka-Flynn, Loretta B., additional, and Lass, Jonathan H., additional

Published
2017
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20. Cornea Preservation Time Study

Author

Lass, Jonathan H., primary, Szczotka-Flynn, Loretta B., additional, Ayala, Allison R., additional, Benetz, Beth A., additional, Gal, Robin L., additional, Aldave, Anthony J., additional, Corrigan, Michelle M., additional, Dunn, Steven P., additional, McCall, Ty L., additional, Pramanik, Sudeep, additional, Rosenwasser, George O., additional, Ross, Kevin W., additional, Terry, Mark A., additional, and Verdier, David D., additional

Published
2015
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21. Randomized, Prospective, Single-Masked Clinical Trial of Endothelial Keratoplasty Performance With 2 Donor Cornea 4°C Storage Solutions and Associated Chambers

Author

Price, Marianne O., primary, Knight, O'Rese J., additional, Benetz, Beth Ann, additional, Debanne, Sara M., additional, Verdier, David D., additional, Rosenwasser, George O., additional, Rosenwasser, Miriam, additional, Price, Francis W., additional, and Lass, Jonathan H., additional

Published
2015
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22. List of Contributors

Author

Abbott, Richard L, Acharya, Nisha R, Aldave, Anthony J, Alfonso, Eduardo C, Allen, Richard C, Al-Mohtaseb, Zaina, Almond, M Camille, Al-Shamekh, Shomoukh, Alvarenga, Lênio Souza, Alward, Wallace LM, Ambrósio, Renato, Jr, Ang, Andrea Y, Ang, Marcus, Anwar, Mohammad, Asbell, Penny A, Azar, Dimitri T, Bahar, Irit, Baik, Annie K, Barney, Neal P, Barry, Brendan C, Barsam, Allon, Bartow, Rebecca M, Baum, Jules, Belin, Michael W, Bell, Jason H, Benetz, Beth Ann, Beuerman, Roger W, Biber, Joseph M, Birnbaum, Andrea D, Bohm, Kelley J, Bouchard, Charles S, Bradley, Jay C, Brandt, James D, Burkat, Cat N, Busin, Massimo, Buznyk, Oleksiy, Cameron, J Douglas, Campos, Mauro, Carpel, Emmett F, Cavanagh, H Dwight, Chai, Jean SM, Chamberlain, Winston, Chan, Clara C, Chang, Bernard H, Chen, Edwin S, Chen, Michael C, Chen, Neil, Chern, Kenneth C, Chodosh, James, Chong, Elaine W, Choulakian, Mazen Y, Chung, Gary, Ciolino, Joseph B, Ciralsky, Jessica, Cortina, Maria Soledad, Crawford, Alexandra Z, de la Cruz, Jose, Damani, Mausam R, Dantas, Paulo Elias C, Darvish-Zargar, Mahshad, Davidson, Richard S, Daya, Sheraz M, Djalilian, Ali R, Donnenfeld, Eric D, Dunn, Steven P, Eagle, Ralph C, Jr, Eghrari, Allen O, Eiferman, Richard A, Eliason, Joseph A, Elies, Daniel, Fagerholm, Per, Farid, Marjan, Farooq, Asim V, Faulkner, William J, Fausett, Blake V, Feder, Robert S, Feiz, Vahid, Felberg, Sergio, Feng, Matthew T, Fontana, Luigi, Foulks, Gary N, de Freitas, Denise, Galor, Anat, Garg, Prashant, Garg, Sumit, Gensheimer, William G, Ghahari, Elham, Glasser, David B, Goins, Kenneth M, Gokoffski, Kimberly K, Goldstein, Debra A, Golen, Jeffrey R, Gomes, Jose, Gonzales, John A, Gottsch, John D, Greenstein, Steven A, Gregory, Darren G, Greiner, Mark A, Griffith, May, Gris, Oscar, Groos, Erich B, Jr, Gruzensky, William D, Güell, Jose L, Guerra, Frederico P, Gupta, Preeya K, Hamill, M Bowes, Hammersmith, Kristin M, Hamrah, Pedram, Hannush, Sadeer B, Hardten, David R, Heidemann, David G, Hersh, Peter S, Hill, Darren C, Hofling-Lima, Ana Luisa, Holland, Edward J, Holland, Gary N, Holland, Stephen, Hong, Augustine R, Honig, Marc A, Hood, Christopher T, Hoskins, Eliza N, Hou, Joshua H, Hsu, Kimberly, Huang, Andrew JW, Huang, David, Hui, Jennifer I, Iovieno, Alfonso, Iuorno, Joseph D, Jackson, W Bruce, Jacobs, Deborah S, Jakobiec, Frederick A, Jeng, Bennie H, Jester, James V, Joag, Madhura G, Jordan, David R, Kanjee, Raageen, Karp, Carol L, Kaufman, Stephen C, Keenan, Jeremy D, Kersten, Robert C, Khachikian, Stephen S, Khanna, Rohit C, Khater, Timothy T, Kim, Eric J, Kim, Michelle J, Kim, Stella K, Kim, Terry, Kinoshita, Shigeru, Kirkness, Colin M, Klyce, Stephen D, Koch, Douglas D, Kohnen, Thomas, Koizumi, Noriko, Kook, Daniel, Kowalski, Regis P, Kruse, Friedrich E, Lai, Edward, Laibson, Peter R, Lass, Jonathan H, Lee, Samuel H, Lee, W Barry, Lemp, Michael A, Li, Jennifer Y, Li, Yan, Lietman, Thomas M, Lim, Michele C, Lin, Lily Koo, Lindquist, T Peter, Lindquist, Thomas D, Lindquist, Timothy P, Lindstrom, Richard L, Litoff, David, Liu, Yu-Chi, Livny, Eitan, LoVerde, Lorena, Lowder, Careen Y, Luz, Allan, Macsai, Marian S, Maio, Mark, Malling, Jackie V, Maltry, Amanda C, Mand, Paramdeep S, Manero, Felicidad, Mannis, Mark J, Mannis, Tova, Martinez, Carlos E, Mártonyi, Csaba L, de la Maza, Maite Sainz, McGee, Hall T, McGhee, Charles NJ, Mehta, Jodhbir, Meisler, David M, Van Meter, Woodford S, Meyer, Jay J, Mian, Shahzad I, Miller, Darlene, Morishige, Naoyuki, Morral, Merce, Moshirfar, Majid, Moss, Adam, Movahedan, Asadolah, Nagra, Parveen, Nanji, Afshan A, Neems, Leslie C, Neff, Kristiana D, Nelson, J Daniel, Nerad, Jeffrey A, Netto, Marcelo V, Ng, Jacqueline, Nijm, Lisa M, Nischal, Ken K, Nishida, Teruo, Nishiwaki-Dantas, M Cristina, Nuijts, Rudy MMA, Nussenblatt, Robert B, Oxford, Karen W, Palay, David A, Palioura, Sotiria, Paranjpe, Deval R, Parikh, Mansi, Parsons, Matthew R, Pasadhika, Sirichai, Patel, Dipika V, Pavlin, Charles J, Pearlstein, Eric S, Pepose, Jay S, Peralta, Robert J, Perez, Mauricio A, Perez, Victor L, Perry, Alicia, Petroll, W Matthew, Pflugfelder, Stephen C, Price, Francis W, Jr, Price, Marianne O, Probst, Louis E, Raizman, Michael B, Raju, Leela V, Rao, Gullapalli N, Raoof, Duna, Rapuano, Christopher J, Reddy, Jagadesh C, Redenbo, Ellen, Reidy, James J, Reilly, Charles D, da Candelaria Renesto, Adimara, Riau, Andri K, Riveroll-Hannush, Lorena, Rizzuti, Allison E, Robertson, Danielle M, Rohr, Ashley, Rootman, David S, Rosenbaum, James T, Sadowsky, Alan E, Saika, Shizuya, Saldanha, Mario J, Salz, James J, Sangwan, Virender S, Sarnicola, Caterina, Sarnicola, Enrica, Sarnicola, Vincenzo, Sayed-Ahmed, Ibrahim O, Sayegh, Rony R, Schmidt, Gregory A, Schteingart, Miriam T, Schwab, Ivan R, Schwam, Brian L, Schwartz, Gary S, Scorcia, Vincenzo, Sen, H Nida, Severinsky, Boris, Shah, Kevin J, Shajari, Mehdi, Shamie, Neda, Shapiro, Brett, Shehadeh-Mashor, Raneen, Shimmura, Shigeto, Shute, Thomas S, Sierra, Patricia B, Bandeira e Silva, Francisco, Sivaraman, Kavitha R, Skolnick, Craig A, Slomovic, Allan R, Snyder, Michael E, Solomon, Renée, Soukiasian, Sarkis H, Barbosa de Sousa, Luciene, Srinivasan, Sathish, Stagner, Anna M, Starr, Christopher E, Steinert, Roger F, Stoica, Bazil TL, Straiko, Michael D, Sugar, Alan, Sugar, Joel, Ta, Christopher N, Tabbara, Khalid F, Tan, Donald TH, Tang, Maolong, Tauber, Joseph, Taylor, Shabnam, Terry, Mark A, Tessler, Howard H, Tourtas, Theofilos, Traboulsi, Elias I, Trattler, William, Trese, Matthew GJ, Tse, David T, Tu, Elmer Y, Vaddavalli, Pravin K, Valenzuela, Felipe A, Varley, Gary A, Verdier, David D, Vickers, Laura A, Vieira, Ana Carolina, Vislisel, Jesse M, Vo, An, Vo, Rosalind C, Vukich, John A, Wade, Matthew, Wang, Jay C, Wang, Li, Waring, George O, III, Waring, George O, IV, Warner, Michael A, Weikert, Mitchell P, Weinstein, Jessica E, Weiss, Jayne S, Weller, Julia M, Wilhelmus, Kirk R, Williamson, Samantha, Wilson, Steven E, Yeu, Elizabeth, Yu, Charles Q, Zhu, Dagny, and Ziaei, Mohammed

Published
2017
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23. Corneal Thickness as a Predictor of Corneal Transplant Outcome

Author

Verdier, David D., primary, Sugar, Alan, additional, Baratz, Keith, additional, Beck, Roy, additional, Dontchev, Mariya, additional, Dunn, Steven, additional, Gal, Robin L., additional, Holland, Edward J., additional, Kollman, Craig, additional, Lass, Jonathan H., additional, Mannis, Mark J., additional, and Penta, Jeffrey, additional

Published
2013
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25. A Multicenter Study to Map Genes for Fuchs Endothelial Corneal Dystrophy: Baseline Characteristics and Heritability

Author

Louttit, Megan D, primary, Kopplin, Laura J, additional, Igo, Robert P, additional, Fondran, Jeremy R, additional, Tagliaferri, Angela, additional, Bardenstein, David, additional, Aldave, Anthony J, additional, Croasdale, Christopher R, additional, Price, Marianne O, additional, Rosenwasser, George O, additional, Lass, Jonathan H, additional, and Iyengar, Sudha K, additional

Published
2012
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38. Effect of Simultaneous Endothelial Keratoplasty and Cataract Surgery: A Secondary Analysis of the Descemet Endothelial Thickness Comparison Trial.

Author

Chamberlain W, Lin CC, Yue J, Cavallino V, Benetz BA, Lass JH, Arnold B, Lietman TM, and Rose-Nussbaumer J

Subjects
Humans, Male, Female, Descemet Membrane surgery, Endothelium, Corneal, Retrospective Studies, Fuchs' Endothelial Dystrophy surgery, Descemet Stripping Endothelial Keratoplasty methods, Cataract complications
Abstract

Purpose: Combining cataract surgery with endothelial keratoplasty (triple EK) is a common practice and may be safer because it commits the patient to only one surgery. This study aimed to determine whether outcomes of pseudophakic endothelial keratoplasty and triple EK have similar outcomes., Methods: This was a non-prespecified secondary analysis of a multicenter, double-masked, randomized, controlled clinical trial. Enrollment centers included the Casey Eye Institute at Oregon Health and Sciences University and the Byers Eye Institute at Stanford University. Patients with damaged or diseased endothelium and were considered good candidates for either Descemet membrane endothelial keratoplasty or ultrathin Descemet stripping automated endothelial keratoplasty were randomized to one of the two surgeries 1-2 days prior to surgery. If the patient had a cataract, they underwent simultaneous cataract surgery. The primary outcome was visual acuity at 6 months. Visual acuity at 3, 12, and 24 months, 3, 6, 12, and 24 month endothelial cell density and intraoperative and postoperative complications were also recorded., Results: Those who had pseudophakic EK generally were older, more likely to be male, and more likely to have worse baseline vision with higher corneal densitometry values. After controlling for baseline visual acuity and type of keratoplasty, those that underwent Triple-EK had 0.09 better LogMAR lines better visual acuity at 6 (95% CI -0.17 to -0.10; P = 0.02) and 12 months (95% CI -0.21 to -0.07; P = 0.03). Although those receiving Triple- EK had nearly one-half LogMAR line better visual acuity at 24 months, it was no longer statistically significant (95% CI -0.20 to -0.05; P = 0.36). There was no statistically significant difference in ECD between groups at any timepoint. Those undergoing triple EK were more likely to have at least one adverse event (P = 0.02)., Conclusions: Earlier intervention with Triple-EK may improve visual acuity outcomes after endothelial keratoplasty compared with staged procedures, but may also increase the risks of adverse events including the need for re-bubble., Competing Interests: The authors have no funding or conflicts of interest to disclose., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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39. Comparison of Donor Corneal Endothelial Cell Density Determined by Eye Banks and by a Central Image Analysis Reading Center Using the Same Image Analysis Method.

Author

Huang H, Benetz BA, Clover JM, Titus M, O'Brien RC, Menegay HJ, and Lass JH

Subjects
Adult, Aged, Cell Count, Corneal Endothelial Cell Loss diagnosis, Endothelial Cells, Endothelium, Corneal, Female, Humans, Middle Aged, Tissue Donors, Eye Banks, Reading
Abstract

Purpose: The purpose of this study was to evaluate agreement between eye banks (EBs) and an image analysis reading center on endothelial cell density (ECD) determinations using the same image analysis method., Methods: The Cornea Image Analysis Reading Center (CIARC) determined ECD with a single experienced analyst on EB-obtained central endothelial images from donors intended for keratoplasty from 2 eye banks, Eversight and Lions VisionGift, using the Konan center analysis method. The EBs performed ECD determination on their respective sets of images using the same analysis method with experienced eye bank technicians., Results: The mean age of the 200 donors was 54 years (range 30-75 years). Seventy (35%) of the 200 patients were women, and 57 (29%) were diabetic. The mean ECD was 10 cells/mm2 greater by the EBs than by CIARC (P = 0.39), with 95% limits of agreement of [-304 to 323 cells/mm2]. The mean difference was not substantially changed when the difference between EBs and CIARC ECD was adjusted for sex, donor age, donor diabetes, CV, HEX, number of cells analyzed, and EBs as a random effect (estimated mean difference of 20 cells/mm2 after adjustment in a linear mixed model; P = 0.73). The EB-determined preoperative ECD was within 10% of the CIARC-determined ECD for 178 (89%) image sets, with 15 (8%) higher by >10% and 7 (3%) lower by >10%., Conclusions: Well-trained eye bank technicians achieve comparable results for ECD determination with an experienced image analyst from an image analysis reading center when the same image analysis method is used., Competing Interests: The authors have no funding or conflicts of interest to disclose., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2022
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40. Baseline donor characteristics in the Cornea Donor Study.

Author

Sugar A, Gal RL, Beck rW, Ruedy KJ, Blanton CL, Feder RS, Hardten DR, Holland EJ, Lass JH, Mannis MJ, and O'Keefe MB

Subjects
Adolescent, Adult, Aged, Cell Count, Child, Cold Temperature, Double-Blind Method, Female, Humans, Male, Middle Aged, Organ Preservation, Time Factors, Tissue and Organ Procurement, Aging, Cornea cytology, Corneal Transplantation, Epithelium, Corneal cytology, Graft Survival, Tissue Donors
Abstract

Purpose: The Cornea Donor Study (CDS) is an ongoing study that is being conducted to determine whether donor age is related to long-term corneal graft survival. Characteristics of the donor population have been evaluated with respect to donor age, endothelial cell density, and death to preservation interval., Methods: Within the context of a prospective, double-masked, controlled trial, 1101 donor corneas were assigned without regard to donor age., Results: Slit-lamp characteristics of the donor corneas showed little variation with donor age, except for the presence of corneal arcus. As death to preservation time decreased, fewer epithelial abnormalities and a lower frequency of stromal edema and Descemet folds were observed. There was little change in the mean of the endothelial cell density with donor age beyond age 60, despite variation., Conclusion: With respect to donor age, there was little difference in either the slit-lamp characteristics or endothelial cell density of the donor corneas. Fewer epithelial abnormalities were observed with shorter death to preservation time.

Published
2005
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