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This introductory article to the special issue on major powers in shared neighbourhoods sets the scenery by introducing the research objectives, situating them in the relevant academic context with references to the literatures on great power dynamics, regionalism and foreign policy analysis. It presents a conceptual framework for the study of ‘major powers’, understood as regional leaders, and their different forms of interaction in shared neighbourhoods, before providing an overview of the key insights of the individual contributions. The article concludes by identifying the main factors explaining the shape of the relationship between major powers in their shared region and outlining a research agenda on comparative neighbourhood policy studies. [ABSTRACT FROM AUTHOR]