1. Solitary circumscribed neuroma of the palpebral conjunctiva: A rare location
- Author
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Hirohiko Kakizaki, Yuichiro Ishida, Yasuhiro Takahashi, and Emiko Takahashi
- Subjects
Male ,Pathology ,medicine.medical_specialty ,CD34 ,Solitary circumscribed neuroma ,Conjunctival Neoplasms ,Schwannoma ,Eyelid Neoplasms ,Palpebral conjunctiva ,Diagnosis, Differential ,Neuroma ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Rare Diseases ,0302 clinical medicine ,Humans ,Medicine ,Neurofibroma ,Local anesthesia ,Pathological ,Aged ,business.industry ,General Medicine ,Anatomy ,medicine.disease ,Ophthalmology ,030221 ophthalmology & optometry ,Clinicopathological features ,sense organs ,business ,Optometry - Abstract
Purpose To report a case with solitary circumscribed neuroma (SCN) in the palpebral conjunctiva. Methods This is a retrospective observational case report of a 78-year-old female who showed a yellowish, smooth-surface, dome-shaped mass in the right lower palpebral conjunctiva near the punctum. The mass was completely removed under local anesthesia. Results Pathological examination revealed that it was composed of benign spindle-shaped cells and tapering nuclei arranged in bundles. Immunocytochemical analyses for the S100, neurofilament, CD34, and epithelial membrane antigens were all positive. These pathological findings were consistent with a SCN. At the 6-month follow-up, there was no evidence of recurrence. Conclusion This is the first case report of SCN in the palpebral conjunctiva. Although SCN had similar clinicopathological features to other benign peripheral nerve sheath tumors, including neurofibroma and schwannoma, immunocytochemical analyses were helpful for correct diagnosis of this case.
- Published
- 2016
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