26 results on '"Spiewak, R."'
Search Results
2. Indications and results of photopatch tests among patch tested patients: FC1.14
- Author
-
Spiewak, R
- Published
- 2012
3. Atopic eczema to food or systemic acd to food haptens?: FS5.05
- Author
-
Spiewak, R
- Published
- 2012
4. “Isaac eczema” - what it really is? Around a half of children and adolescents with eczema detected with the ISAAC questionnaire are in fact ill with allergic contact dermatitis: FC1.06
- Author
-
Spiewak, R. and Czarnobilska, E.
- Published
- 2010
5. Contact allergy among polish children and adolescents with dermatitis: FS09.6
- Author
-
Czarnobilska, E., Dyga, W., Obtulowicz, A., Obtulowicz, K., and Spiewak, R.
- Published
- 2008
6. Risk factors for work-related dermatoses among farming students
- Author
-
Spiewak, R.
- Published
- 2006
7. In vitro diagnosis of nickel allergy
- Author
-
Spiewak, R., Moed, H., von Blomberg, B. M.E., Bruynzeel, D. P., Scheper, R. J., Gibbs, S., and Rustemeyer, T.
- Published
- 2006
8. Occupational airborne contact dermatitis caused by thyme dust
- Author
-
Spiewak, R., Skorska, C., and Dutkiewicz, J.
- Published
- 2001
9. Severely compromised supply of patch test allergens in Europe hampers adequate diagnosis of occupational and non-occupational contact allergy. A European Society of Contact Dermatitis (ESCD), European Academy of Allergy and Clinical Immunology (EAACI), European Academy of Dermatology and Venereology (EADV) task forces 'Contact Dermatitis' and 'Occupational Skin Disease' position paper.
- Author
-
John SM, Bonertz A, Zimmer J, Aerts O, Bauer A, Bova M, Brans R, Del Giacco S, Dickel H, Corazza M, Crépy MN, Gallo R, Garcia-Abujeta JL, Giménez-Arnau AM, Klimek L, Lepoittevin JP, Ljubojević Hadžavdić S, Matura M, Mortz CG, Özkaya E, Pesonen M, Raison-Peyron N, Rustemeyer T, Skudlik C, Spiewak R, Stingeni L, Suomela S, Symanzik C, Taylor J, Torres M, Uter W, White I, Wilkinson M, Mahler V, and Johansen JD
- Subjects
- Humans, Europe, Societies, Medical, Advisory Committees, Patch Tests methods, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology, Allergens adverse effects, Dermatitis, Occupational diagnosis, Dermatitis, Occupational etiology
- Abstract
Patch testing is the only clinically applicable diagnostic method for Type IV allergy. The availability of Type IV patch test (PT) allergens in Europe, however, is currently scarce. This severely compromises adequate diagnostics of contact allergy, leading to serious consequences for the affected patients. Against this background, the European Society of Contact Dermatitis (ESCD) has created a task force (TF) (i) to explore the current availability of PT substances in different member states, (ii) to highlight some of the unique characteristics of Type IV vs. other allergens and (iii) to suggest ways forward to promote and ensure availability of high-quality patch testing substances for the diagnosis of Type IV allergies throughout Europe. The suggestions of the TF on how to improve the availability of PT allergens are supported by the ESCD, the European Academy of Allergy and Clinical Immunology, and the European Academy of Dermatology and Venereology and intend to provide potential means to resolve the present medical crisis., (© 2024 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
10. Occupational contact allergy: The European perspective-Analysis of patch test data from ESSCA between 2011 and 2020.
- Author
-
Bauer A, Pesonen M, Brans R, Caroppo F, Dickel H, Dugonik A, Larese Filon F, Geier J, Gimenez-Arnau AM, Napolitano M, Patruno C, Rustemeyer T, Simon D, Schuttelaar MLA, Spiewak R, Stingeni L, Vok M, Weisshaar E, Wilkinson M, Valiukeviciene S, and Uter W
- Subjects
- Humans, Patch Tests adverse effects, Rubber, Epoxy Resins, Allergens, Benzothiazoles, Dermatitis, Allergic Contact etiology, Dermatitis, Occupational etiology
- Abstract
Background: Occupational skin diseases have led the occupational disease statistics in Europe for many years. Especially occupational allergic contact dermatitis is associated with a poor prognosis and low healing rates leading to an enormous burden for the affected individual and for society., Objectives: To present the sensitization frequencies to the most relevant allergens of the European baseline series in patients with occupational contact dermatitis (OCD) and to compare sensitization profiles of different occupations., Methods: The data of 16 022 patients considered having OCD after patch testing within the European Surveillance System on Contact Allergies (ESSCA) network between January 2011 and December 2020 were evaluated. Patients (n = 46 652) in whom an occupational causation was refuted served as comparison group., Results: The highest percentages of OCD were found among patients working in agriculture, fishery and related workers, metal industry, chemical industry, followed by building and construction industry, health care, food and service industry. Sensitizations to rubber chemicals (thiurams, carbamates, benzothiazoles) and epoxy resins were associated with at least a doubled risk of OCD. After a decline from 2014 onwards, the risks to acquire an occupation-related sensitization to methyl(chloro)isothiazolinone (MCI/MI) and especially to methylisothiazolinone (MI) seem to increase again. Sensitization rates to formaldehyde were stable, and to methyldibromo glutaronitrile (MDBGN) slightly decreasing over time., Conclusions: Among allergens in the European Baseline Series, occupational relevance is most frequently attributed to rubber accelerators, epoxy resins and preservatives., (© 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
11. The European baseline series and recommended additions: 2023.
- Author
-
Wilkinson SM, Gonçalo M, Aerts O, Badulici S, Dickel H, Gallo R, Garcia-Abujeta JL, Giménez-Arnau AM, Hamman C, Hervella M, Isaksson M, Johansen JD, Mahler V, Niklasson B, Pigatto P, Ponyai G, Rustemeyer T, Schuttelaar MLA, Spiewak R, Stingeni L, Thyssen JP, and Uter W
- Subjects
- Humans, Allergens, Patch Tests, Europe, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology
- Abstract
The European baseline series was last updated in 2019. This article discusses the reasoning behind a further iteration of the series for 2023., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
12. Guidelines for diagnosis, prevention, and treatment of hand eczema.
- Author
-
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, and Agner T
- Subjects
- Humans, Patch Tests, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact prevention & control, Eczema diagnosis, Eczema prevention & control, Hand Dermatoses diagnosis, Hand Dermatoses prevention & control
- Abstract
Background: Hand eczema is a common inflammatory skin disorder. Health care providers need continuously updated information about the management of hand eczema to ensure best treatment for their patients., Objectives: To update the European Society of Contact Dermatitis guideline on the diagnosis, prevention, and treatment on of hand eczema., Method: The Guideline Development Group (GDG) was established on behalf of the ESCD. A call for interest was launched via the ESCD website and via the ESCD members' mailing list. Appraisal of the evidence for therapeutic and preventive interventions was applied and a structured method of developing consensus was used and moderated by an external methodologist. The final guideline was approved by the ESCD executive committee and was in external review on the ESCD webpage for 1 month., Results: Consensus was achieved for several statements and management strategies., Conclusion: The updated guideline should improve management of hand eczema., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2022
- Full Text
- View/download PDF
13. European Surveillance System on Contact Allergies (ESSCA): Characteristics of patients patch tested and diagnosed with irritant contact dermatitis.
- Author
-
Loman L, Uter W, Armario-Hita JC, Ayala F, Balato A, Ballmer-Weber BK, Bauer A, Bircher AJ, Buhl T, Czarnecka-Operacz M, Dickel H, Fuchs T, Giménez Arnau A, John SM, Kränke B, Kręcisz B, Mahler V, Rustemeyer T, Sadowska-Przytocka A, Sánchez-Pérez J, Scherer Hofmeier K, Schliemann S, Simon D, Spiewak R, Spring P, Valiukevičienė S, Wagner N, Weisshaar E, Pesonen M, and Schuttelaar MLA
- Abstract
Background: Irritant contact dermatitis (ICD) is caused by the acute locally toxic effect of a strong irritant, or the cumulative exposure to various weaker physical and/or chemical irritants., Objectives: To describe the characteristics of patients with ICD in the population patch tested in the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) database., Methods: Data collected by the ESSCA in consecutively patch-tested patients from January 2009 to December 2018 were analyzed., Results: Of the 68 072 patients, 8702 were diagnosed with ICD (without concomitant allergic contact dermatitis [ACD]). Hand and face were the most reported anatomical sites, and 45.7% of the ICD was occupational ICD (OICD). The highest proportions of OICD were found in metal turners, bakers, pastry cooks, and confectionery makers. Among patients diagnosed with ICD, 45% were found sensitized with no relevance for the current disease., Conclusions: The hands were mainly involved in OICD also in the subgroup of patients with contact dermatitis, in whom relevant contact sensitization had been ruled out, emphasizing the need for limiting irritant exposures. However, in difficult-to-treat contact dermatitis, unrecognized contact allergy, or unrecognized clinical relevance of identified allergies owing to incomplete or wrong product ingredient information must always be considered., (Contact Dermatitis© 2021 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
14. Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015-2018.
- Author
-
Uter W, Bauer A, Belloni Fortina A, Bircher AJ, Brans R, Buhl T, Cooper SM, Czarnecka-Operacz M, Dickel H, Dugonik A, Geier J, Giménez-Arnau AM, Gonçalo M, Johansen JD, Johnston GA, Mahler V, Rustemeyer T, Sanchez-Perez J, Schuttelaar MLA, Simon D, Spiewak R, Valiukevičienė S, Weisshaar E, White IR, and Wilkinson M
- Subjects
- Allergens, Balsams adverse effects, Dermatitis, Allergic Contact epidemiology, Europe epidemiology, Humans, Nickel adverse effects, Odorants, Population Surveillance, Prevalence, Thiazoles adverse effects, Dermatitis, Allergic Contact diagnosis, Patch Tests methods
- Abstract
Background: Clinical surveillance of the prevalence of contact allergy in consecutively patch tested patients is a proven instrument to continually assess the importance of contact allergens (haptens) assembled in a baseline series., Objectives: To present current results from the European Surveillance System on Contact Allergies, including 13 countries represented by 1 to 11 departments., Methods: Anonymized or pseudonymized patch test and clinical data from various data capture systems used locally or nationally as transferred to the Erlangen data centre were pooled and descriptively analysed after quality control., Results: In the 4 years (2015-2018), data from 51 914 patients patch tested with the European baseline series (EBS) of contact allergens were analysed. Contact allergy to nickel was most frequent (17.6% positive), followed by contact allergy to fragrance mix I (6.9%), methylisothiazolinone (MI; 6.2%), and Myroxylon pereirae resin (balsam of Peru; 5.8%)., Conclusions: While the prevalence of MI contact allergy decreased substantially following regulatory intervention, the persistently high levels of allergy to metals, fragrances, other preservatives, and rubber chemicals point to problems needing further research and, potentially, preventive efforts. Results with national additions to the baseline series provide important information on substances possibly to be considered for inclusion in the EBS., (© 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
15. The European baseline series and recommended additions: 2019.
- Author
-
Wilkinson M, Gonçalo M, Aerts O, Badulici S, Bennike NH, Bruynzeel D, Dickel H, Garcia-Abujeta JL, Giménez-Arnau AM, Hamman C, Isaksson M, Johansen JD, Mahler V, Niklasson B, Orton D, Pigatto P, Ponyai G, Rustemeyer T, Schuttelaar MLA, Spiewak R, Thyssen JP, and Uter W
- Subjects
- Europe, Humans, Allergens, Dermatitis, Allergic Contact diagnosis, Patch Tests
- Published
- 2019
- Full Text
- View/download PDF
16. European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009-2014.
- Author
-
Dittmar D, Uter W, Bauer A, Fortina AB, Bircher AJ, Czarnecka-Operacz M, Dugonik A, Elsner P, Gallo R, Ghaffar SA, Giménez-Arnau A, Johnston GA, Kręcisz B, Filon FL, Rustemeyer T, Sadowska-Przytocka A, Sánchez-Pérez J, Schnuch A, Simon D, Spiewak R, Spring P, Corradin MT, Valiukevičienė S, Vok M, Weisshaar E, Wilkinson M, and Schuttelaar ML
- Subjects
- Adult, Dermatitis, Allergic Contact epidemiology, Dermatitis, Allergic Contact immunology, Dermatitis, Atopic epidemiology, Europe epidemiology, Humans, Middle Aged, Prevalence, Retrospective Studies, Young Adult, Allergens immunology, Patch Tests statistics & numerical data, Population Surveillance
- Abstract
Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life., Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization., Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed., Results: A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization., Conclusions: The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Known risk factors for polysensitization are confirmed in a European dermatitis population., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
17. Patch testing with rubber series in Europe: a critical review and recommendation.
- Author
-
Warburton KL, Uter W, Geier J, Spiewak R, Mahler V, Crépy MN, Schuttelaar ML, Bauer A, and Wilkinson M
- Subjects
- Dermatitis, Allergic Contact epidemiology, Dermatitis, Allergic Contact etiology, Dermatitis, Occupational epidemiology, Dermatitis, Occupational etiology, Female, Humans, Latex Hypersensitivity epidemiology, Latex Hypersensitivity etiology, Male, Occupations, Prevalence, Dermatitis, Allergic Contact diagnosis, Dermatitis, Occupational diagnosis, Latex Hypersensitivity diagnosis, Patch Tests methods, Rubber adverse effects
- Abstract
Background: Rubber additives constitute an important group of contact allergens, particularly in certain occupations., Objectives: To collect information regarding the current practice of using a 'rubber series' in Europe, and discuss this against the background of evidence concerning the prevalence of allergy in order to derive a recommendation for a 'European rubber series'., Methods: The following were performed: (i) a survey targeting all members of the COST action 'StanDerm' consortium, (ii) analysis of rubber contact allergy data in the database of the European Surveillance System on Contact Allergies, and (iii) a literature review., Results: Information from 13 countries was available, from one or several departments of dermatology, and occasionally occupational health. Apart from some substances tested only in single departments, a broad overlap regarding important allergens was evident, but considerable variation existed between departments., Conclusions: An up-to-date 'European rubber series' is recommended, with the exclusion of substances only of historical concern. A 'supplementary rubber series' containing allergens of less proven importance, requiring further analysis, is recommended for departments specializing in occupational contact allergy. These should be continually updated as new evidence emerges., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
- Full Text
- View/download PDF
18. Assessment of chromium(VI) release from 848 jewellery items by use of a diphenylcarbazide spot test.
- Author
-
Bregnbak D, Johansen JD, Hamann D, Hamann CR, Hamann C, Spiewak R, Menné T, Zachariae C, Jellesen MS, and Thyssen JP
- Subjects
- Spectrometry, X-Ray Emission, Chromium analysis, Diphenylcarbazide, Indicators and Reagents, Jewelry analysis
- Published
- 2016
- Full Text
- View/download PDF
19. Jewellery: alloy composition and release of nickel, cobalt and lead assessed with the EU synthetic sweat method.
- Author
-
Hamann D, Thyssen JP, Hamann CR, Hamann C, Menné T, Johansen JD, Spiewak R, Maibach H, Lundgren L, and Lidén C
- Subjects
- Dermatitis, Allergic Contact etiology, Humans, Jewelry adverse effects, Spectrometry, X-Ray Emission, Spectrum Analysis methods, Sweat, Alloys analysis, Cobalt analysis, Jewelry analysis, Nickel analysis
- Abstract
Background: Several studies have shown nickel and cobalt release from jewellery by using spot tests, but the metal composition of jewellery is largely unknown., Objectives: To evaluate the metal composition of a large worldwide sample of mainly inexpensive jewellery items, and investigate the release of nickel, cobalt and lead from a subsample by using EN 1811:1998-required methods., Methods: A total of 956 metallic jewellery components were examined with X-ray fluorescence spectroscopy. A subsample of 96 jewellery items purchased in the United States were investigated for nickel, cobalt and lead release by the use of artificial sweat immersion and plasma optical emission spectroscopy., Results: Eighteen elements were detected. The 10 most frequently occurring were, in order of frequency, copper, iron, zinc, nickel, silver, chromium, tin, manganese, lead, and cobalt. Release of nickel was noted from 79 of the 96 US samples (0.01-98 µg/cm(2) /week), release of cobalt from 35 samples (0.02-0.5 µg/cm(2) /week), and release of lead from 37 samples (0.03-2718 µg/cm(2) /week)., Conclusions: We present here a comprehensive list of the most frequently encountered metals in jewellery and fashion accessories. Different allergenic and non-allergenic metals are utilized. We also report the frequent release of nickel, cobalt and lead from these objects, despite legislative restrictions., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2015
- Full Text
- View/download PDF
20. European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice.
- Author
-
Johansen JD, Aalto-Korte K, Agner T, Andersen KE, Bircher A, Bruze M, Cannavó A, Giménez-Arnau A, Gonçalo M, Goossens A, John SM, Lidén C, Lindberg M, Mahler V, Matura M, Rustemeyer T, Serup J, Spiewak R, Thyssen JP, Vigan M, White IR, Wilkinson M, and Uter W
- Subjects
- Adult, Allergens administration & dosage, Child, Dermatitis, Occupational diagnosis, Drug Eruptions diagnosis, Humans, Hypersensitivity, Delayed diagnosis, Patient Education as Topic, Dermatitis, Allergic Contact diagnosis, Patch Tests adverse effects, Patch Tests methods
- Abstract
The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement. Finally, short reference is made to aspects of (continuing) medical education and to electronic collection of data for epidemiological surveillance., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2015
- Full Text
- View/download PDF
21. Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008.
- Author
-
Uter W, Aberer W, Armario-Hita JC, Fernandez-Vozmediano JM, Ayala F, Balato A, Bauer A, Ballmer-Weber B, Beliauskiene A, Fortina AB, Bircher A, Brasch J, Chowdhury MM, Coenraads PJ, Schuttelaar ML, Cooper S, Czarnecka-Operacz M, Zmudzinska M, Elsner P, English JS, Frosch PJ, Fuchs T, García-Gavín J, Fernández-Redondo V, Gawkrodger DJ, Giménez-Arnau A, Green CM, Horne HL, Johansen JD, Jolanki R, Pesonen M, King CM, Krêcisz B, Chomiczewska D, Kiec-Swierczynska M, Larese F, Mahler V, Ormerod AD, Peserico A, Rantanen T, Rustemeyer T, Sánchez-Pérez J, Sansom JE, Silvestre JF, Simon D, Spiewak R, Statham BN, Stone N, Wilkinson M, and Schnuch A
- Subjects
- Europe epidemiology, Female, Humans, Incidence, Male, Metals toxicity, Occupational Diseases diagnosis, Occupational Diseases epidemiology, Perfume adverse effects, Prevalence, Allergens, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact epidemiology, Patch Tests
- Abstract
Background: The pattern of contact sensitization to the supposedly most important allergens assembled in the baseline series differs between countries, presumably at least partly because of exposure differences. Objectives. To describe the prevalence of contact sensitization to allergens tested in consecutive patients in the years 2007 and 2008, and to discuss possible differences., Methods: Data from the 39 departments in 11 European countries comprising the European Surveillance System on Contact Allergy network (www.essca-dc.org) in this period have been pooled and analysed according to common standards., Results: Patch test results with the European baseline series, and country-specific or department-specific additions to it, obtained in 25 181 patients, showed marked international variation. Metals and fragrances are still the most frequent allergens across Europe. Some allergens tested nationally may be useful future additions to the European baseline series, for example methylisothiazolinone, whereas a few long-term components of the European baseline series, namely primin and clioquinol, no longer warrant routine testing., Conclusions: The present analysis points to 'excess' prevalences of specific contact sensitization in some countries, although interpretation must be cautious if only few, and possibly specialized, centres are representing one country. A comparison as presented may help to target in-depth research into possible causes of 'excess' exposure, and/or consideration of methodological issues, including modifications to the baseline series., (© 2012 John Wiley & Sons A/S.)
- Published
- 2012
- Full Text
- View/download PDF
22. The EU Nickel Directive revisited--future steps towards better protection against nickel allergy.
- Author
-
Thyssen JP, Uter W, McFadden J, Menné T, Spiewak R, Vigan M, Gimenez-Arnau A, and Lidén C
- Subjects
- Dermatitis, Allergic Contact epidemiology, European Union, Female, Humans, Nickel toxicity, Allergens toxicity, Consumer Product Safety legislation & jurisprudence, Dermatitis, Allergic Contact prevention & control, Nickel standards
- Abstract
In July 2001, the EU Nickel Directive came into full force to protect European citizens against nickel allergy and dermatitis. Prior to this intervention, Northern European governments had already begun to regulate consumer nickel exposure. According to part 2 of the EU Nickel Directive and the Danish nickel regulation, consumer items intended to be in direct and prolonged contact with the skin were not allowed to release more than 0.5 µg nickel/cm2/week. It was considered unlikely that nickel allergy would disappear altogether as a proportion of individuals reacted below the level defined by the EU Nickel Directive. Despite this, the EU Nickel Directive part 2 was expected to work as an operational limit that would sufficiently protect European consumers against nickel allergy and dermatitis. This review presents the accumulation of epidemiological studies that evaluated the possible effect of this major public health intervention. Also, it evaluates recent exposure assessment studies that have been performed using the dimethyl glyoxime test. It is concluded that the EU Nickel Directive has started to change the epidemiology of nickel allergy in Europe but it should be revisited to better protect consumers and workers since nickel allergy and dermatitis remain very frequent., (© 2011 John Wiley & Sons A/S.)
- Published
- 2011
- Full Text
- View/download PDF
23. Cutaneous adverse drug reaction to heparins with hypereosinophilia and high IgE level.
- Author
-
Klos K, Spiewak R, Kruszewski J, and Bant A
- Subjects
- Drug Eruptions blood, Drug Eruptions etiology, Eosinophilia blood, Exanthema blood, Humans, Immunoglobulin E blood, Male, Middle Aged, Urticaria blood, Venous Thrombosis drug therapy, Exanthema chemically induced, Fibrinolytic Agents adverse effects, Heparin adverse effects, Urticaria chemically induced
- Published
- 2011
- Full Text
- View/download PDF
24. Contact hypersensitivity and allergic contact dermatitis among school children and teenagers with eczema.
- Author
-
Czarnobilska E, Obtulowicz K, Dyga W, Wsolek-Wnek K, and Spiewak R
- Subjects
- Adolescent, Child, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact epidemiology, Dermatitis, Allergic Contact etiology, Dermatitis, Contact diagnosis, Dermatitis, Contact etiology, Eczema diagnosis, Eczema epidemiology, Female, Humans, Male, Mass Screening, Patch Tests, Poland epidemiology, Surveys and Questionnaires, Dermatitis, Contact epidemiology, Eczema chemically induced
- Abstract
Background: Patch testing is an essential procedure in the investigation of eczema in children., Objectives: To analyse the frequency of contact hypersensitivity and allergic contact dermatitis among Polish children with eczema., Patients/methods: During an allergy screening programme involving 9320 children aged 7 and 16 years, 12.6% reported symptoms of chronic/recurrent eczema. From this group, a representative sample of 229 eczema children underwent patch testing: 96 children aged 7 years and 133 teenagers aged 16 years. Patch testing was with 10 allergens: methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), nickel sulfate, mercury ammonium chloride, thimerosal, cobalt chloride, potassium dichromate, lanolin, fragrance mix I, Myroxylon pereirae (balsam of Peru), and colophonium., Results: 49.4% tested children were found patch test (PT) positive. 43.8% of 7 year olds with eczema were PT positive, with sensitization to nickel sulfate (30.2%), thimerosal (10.4%), cobalt chloride (8.3%), fragrance mix I (7.3%), MCI/MI (6.3%), potassium dichromate (6.3%), M. pereirae (3.1%), mercury ammonium chloride (2.3%), and colophonium (1.0%). 52.6% teenagers were PT positive, with sensitization to nickel sulfate (23.3%), thimerosal (27.8%), cobalt chloride (10.5%), potassium dichromate (6.0%), mercury ammonium chloride (2.3%), M. pereirae (1.5%), and MCI/MI (0.8%). The final diagnosis of allergic contact dermatitis was confirmed in 36% of 7 year olds and 26% of 16 year olds., Conclusions: Every second child with eczema is PT positive, whereas every third child is finally diagnosed with allergic contact dermatitis.
- Published
- 2009
- Full Text
- View/download PDF
25. Allergic contact dermatitis to nickel: modified in vitro test protocols for better detection of allergen-specific response.
- Author
-
Spiewak R, Moed H, von Blomberg BM, Bruynzeel DP, Scheper RJ, Gibbs S, and Rustemeyer T
- Subjects
- Case-Control Studies, Culture Techniques, Dermatitis, Allergic Contact pathology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interferon-gamma biosynthesis, Interleukins biosynthesis, Predictive Value of Tests, Allergens immunology, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact immunology, Nickel immunology, Th1 Cells immunology, Th2 Cells immunology
- Abstract
To date, no in vitro test is suitable for routine diagnosis of contact allergy. The aim of our study was to establish improved in vitro test protocol for the detection of antigen-specific responses of lymphocytes from patients with allergic contact dermatitis to nickel (Ni-ACD). Blood leucocytes from 14 Ni-ACD patients and 14 controls were cultured in the presence of 'cytokine cocktails' skewing lymphocytes towards 'type 1' [interferon-gamma (IFN-gamma)-secreting] or 'type 2' [interleukin (IL)-5 and IL-13-secreting] phenotypes. The cocktails consisted of IL-7 and, respectively, either IL-12 or IL-4. Cell responses to nickel were measured with enzyme-linked immunospot assay (ELISpot), enzyme-linked immunosorbent assay (ELISA), and lymphocyte proliferation test (LPT). Significant differences between patients with Ni-ACD and controls were found for the 'type 2' cytokines IL-13 and IL-5, with further increase of allergen-specific responses occurring when cultures were supplemented with IL-7 and IL-4. No significant differences were found for IFN-gamma. The best correlate to clinical diagnosis was LPT with 'type 2' skewing (r= 0.739, P < 0.001), followed by IL-13 ELISpot with 'type 2' skewing (r= 0.654, P < 0.001). The non-radioactive method that correlated best with LPT was IL-2 ELISpot (r= 0.809, P < 0.001). Overall, we conclude that combining ELISpot assay with proposed modifications of culture conditions improves detection of specific lymphocyte responses in contact allergy to nickel.
- Published
- 2007
- Full Text
- View/download PDF
26. Köbnerizing occupational contact allergy to thiuram in a farmer with psoriasis.
- Author
-
Spiewak R
- Subjects
- Adult, Agricultural Workers' Diseases etiology, Dermatitis, Allergic Contact etiology, Dermatitis, Occupational etiology, Female, Fungicides, Industrial administration & dosage, Gloves, Protective adverse effects, Hand Dermatoses etiology, Humans, Psoriasis chemically induced, Risk Factors, Thiram administration & dosage, Time Factors, Agricultural Workers' Diseases diagnosis, Dermatitis, Allergic Contact diagnosis, Dermatitis, Occupational diagnosis, Fungicides, Industrial adverse effects, Psoriasis etiology, Thiram adverse effects
- Published
- 2004
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.