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• Extended and revised versions of the three best contributions of STAG 2019 conference. • A framework for interactive space-time exploration of massive timedependent volume data. • A web-based visualization tool for improving scientific reviewer selection tasks. • A VR environment for editing and proof-reading skeletons of branched brain cellular morphologies. This special issue contains extended and revised versions of the best papers presented at the 6th Smart Tools and Applications in Graphics (STAG 2019), held in Cagliari, on 14–15 November, 2019. The three selected papers span different visual computing domains: (i) a framework for fully interactive non-linear spatio-temporal exploration of massive time-varying rectilinear scalar volumes on commodity platforms, (ii) a visualization system for reviewers for identifying researchers working on a certain topic, analyzing their contributions over time, and highlighting co-authorship relations and conflicts, (iii) a VR environment for editing and proofreading medial axis representations of nanoscale brain cell morphologies. [ABSTRACT FROM AUTHOR]