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• Automatic Plant disease diagnosis for early disease symptoms. • Novel image processing algorithm in combination with machine learning methods. • A testing on wheat was performed with 7 mobile devices over a period of 4 seasons. • Obtained results reveal AuC metrics higher than 0.80 for all the analyzed diseases. Fungal infection represents up to 50 % of yield losses, making it necessary to apply effective and cost efficient fungicide treatments, whose efficacy depends on infestation type, situation and time. In these cases, a correct and early identification of the specific infection is mandatory to minimize yield losses and increase the efficacy and efficiency of the treatments. Over the last years, a number of image analysis-based methodologies have been proposed for automatic image disease identification. Among these methods, the use of Deep Convolutional Neural Networks (CNNs) has proven tremendously successful for different visual classification tasks. In this work we extend previous work by Johannes et al. (2017) with an adapted Deep Residual Neural Network-based algorithm to deal with the detection of multiple plant diseases in real acquisition conditions where different adaptions for early disease detection have been proposed. This work analyses the performance of early identification of three relevant European endemic wheat diseases: Septoria (Septoria triciti), Tan Spot (Drechslera triciti-repentis) and Rust (Puccinia striiformis & Puccinia recondita). The analysis was done using different mobile devices, and more than 8178 images were captured in two pilot sites in Spain and Germany during 2014 , 2015 and 2016. Obtained results reveal an overall improvement of the balanced accuracy from 0.78 (Johannes et al., 2017) up to 0.87 under exhaustive testing, and balanced accuracies greater than 0.96 on a pilot test performed in Germany. [ABSTRACT FROM AUTHOR]