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A solid oxide fuel cell-based (SOFC) power generation plant is analyzed with a view to performance as well as thermo-mechanical stresses. Emphasis is given to design and operation constraints of individual components as well as control-relevant aspects. We use a multi-physics modeling approach for simulations in design and off-design (part-load) under steady-state and transient conditions. Simulations confirm that the temperature distribution plays a pivotal role. For the SOFC the electrolyte is exposed to higher stresses compared to those in the electrodes. Disturbances in operation, e.g. in terms of current extraction, should be avoided because of resulting temperature excursions. This systems engineering perspective in which performance, durability issues and control aspects are combined, provides additional insights on a system level of practical relevance. [ABSTRACT FROM AUTHOR]