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Start Over Journal comptes rendus des seances de la societe de biologie et de ses filiales Region belgium Publisher masson
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1. [Relative biological effectiveness (RBE) of d(50)-Be neutrons (Louvain-la-Neuve) and p(34)-Be neutrons (Orleans) for early intestinal tolerance in mice].

Author

Gueulette J, Breteau N, Sabattier R, and Wambersie A

Subjects
Animals, Belgium, Beryllium, France, Intestinal Mucosa radiation effects, Lethal Dose 50, Mice, Mice, Inbred BALB C, Relative Biological Effectiveness, Neutrons, Particle Accelerators, Radiation Tolerance
Abstract

This paper compares the RBE of a neutron beam produced by 50 MeV deuterons on beryllium [d(50)-Be] at the cyclotron CYCLONE of Louvain-La-Neuve and of a neutron beam produced by 34 MeV protons on beryllium [p(34)-Be] of the Hôpital Régional d'Orléans. Early intestinal tolerance in mice was choosen as biological criterium; it is derived from LD50 determination after single and fractionated abdominal irradiation. For d(50)-Be neutrons, RBE was 1.8 +/- 0.2 (with respect to 60Co gamma-rays) for a single fraction. It increases up to 2.1 +/- 0.2 for an irradiation in 2 fractions (3.5 h interval) and reaches 2.5 +/- 0.3, 2.7 +/- 0.3 and 2.5 +/- 0.3 for irradiations in 10 fractions (7 and 3.5 h interval) and 20 fractions (3.5 h interval) respectively. RBE values observed for p(34)-Be neutrons (with respect to 60Co gamma-rays) are not significantly different. For a single fraction RBE = 1.7 +/- 0.2 and for 2 fractions (3.5 h interval) RBE = 2.0 +2- 0.2.

Published
1982