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Your search keyword '"overdominance"' showing total 2 results
Start Over "overdominance" Language french Journal comptes rendus des seances de la societe de biologie et de ses filiales
2 results on '"overdominance"'

1. [Genetics of insulin-dependent juvenile diabetes]

Author

C, Raffoux, F, Streiff, J P, Pointel, and G, Debry

Subjects
Male, Diabetes Mellitus, Type 1, HLA Antigens, Humans, Female, Antigens, Child, Pedigree
Abstract

Since the works of Singal and al. and Nerup and al., an increase in B 8, B 15 and B 18 antigens has been found in Insulin Dependent Diabetes. Thomson and al., Rubinstein and al. and the authors of this paper have shown an stronger association with DRw 3 and DRw 4 antigens. We investigated the genetic predisposition to juvenile diabetes in 22 families of 48 cases and 96 members. The study of one affected child in each family showed that DRw 3 was found in 63,63% and DRw 4 in 59,59% (healthy 16,22%)--RR = 9,0 and 7,49. The hypothesis of overdominance proposed by Nerup can be confirmed by our data, when I.D.D.M. share two different alleles (DRw 3 and DRw 4). 3 particular haplotypes with linkage imbalance are therefore observed in our series: B 8-Bf S-DRw 3, B 15-Bf F-DRw 4 and B 8-Bf F 1-DRw 3. Our date show a excessive transmission of the diabetic haplotype by parents who are either diabetics or carriers of the gene.

Published
1980

2. [Genetics of insulin-dependent juvenile diabetes].

Author

Raffoux C, Streiff F, Pointel JP, and Debry G

Subjects
Child, Diabetes Mellitus, Type 1 immunology, Female, HLA Antigens genetics, Humans, Male, Pedigree, Antigens genetics, Diabetes Mellitus, Type 1 genetics
Abstract

Since the works of Singal and al. and Nerup and al., an increase in B 8, B 15 and B 18 antigens has been found in Insulin Dependent Diabetes. Thomson and al., Rubinstein and al. and the authors of this paper have shown an stronger association with DRw 3 and DRw 4 antigens. We investigated the genetic predisposition to juvenile diabetes in 22 families of 48 cases and 96 members. The study of one affected child in each family showed that DRw 3 was found in 63,63% and DRw 4 in 59,59% (healthy 16,22%)--RR = 9,0 and 7,49. The hypothesis of overdominance proposed by Nerup can be confirmed by our data, when I.D.D.M. share two different alleles (DRw 3 and DRw 4). 3 particular haplotypes with linkage imbalance are therefore observed in our series: B 8-Bf S-DRw 3, B 15-Bf F-DRw 4 and B 8-Bf F 1-DRw 3. Our date show a excessive transmission of the diabetic haplotype by parents who are either diabetics or carriers of the gene.

Published
1980

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