1. Role of brain nitric oxide in the cardiovascular control of bullfrogs
- Author
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Luciane H. Gargaglioni, Kênia C. Bícego, Lucas A. Zena, Universidade Estadual Paulista (Unesp), and INCT-Fisiologia Comparada
- Subjects
Male ,systolic blood pressure ,alpha adrenergic receptor ,Physiology ,Blood Pressure ,bullfrog ,hexamethonium ,Biochemistry ,sotalol ,Body Temperature ,chemistry.chemical_compound ,Bullfrog ,Heart Rate ,heart rate ,Medicine ,Telemetry ,Adrenergic receptors ,Enzyme Inhibitors ,l-NMMA ,Skin ,Rana catesbeiana ,Sotalol ,Brain ,Injections, Intravenous ,Omega-N-Methylarginine ,mean arterial pressure ,Hexamethonium ,arterial pressure ,medicine.drug ,medicine.medical_specialty ,Mean arterial pressure ,brain ,beta adrenergic receptor ,Adrenergic beta-Antagonists ,Ganglionic blocker ,n(g) methylarginine ,Nitric Oxide ,Nitric oxide ,nitric oxide ,Internal medicine ,Prazosin ,Animals ,L-NMMA ,Molecular Biology ,Injections, Intraventricular ,prazosin ,nonhuman ,omega-N-Methylarginine ,business.industry ,aorta arch ,diastolic blood pressure ,Endocrinology ,Blood pressure ,chemistry ,skin blood vessel ,cardiovascular system ,Adrenergic alpha-1 Receptor Antagonists ,business ,body temperature ,sympathetic tone - Abstract
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:29:34Z No. of bitstreams: 0 Made available in DSpace on 2014-05-27T11:29:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-06-01 The goal of the present study was to determine if nitric oxide (NO) acting on the brain of bullfrog (Lithobates catesbeianus) is involved in arterial pressure and heart rate (HR) control by influencing sympathetic activity. We investigated the effect of intracerebroventricular injections of l-NMMA (a nonselective NO synthase inhibitor) on mean arterial blood pressure (MAP), HR and cutaneous vascular conductance (CVC) of pelvic skin after intravenous injection of α or β adrenergic blockers, prazosin or sotalol, respectively. Arterial pressure was directly measured by a telemetry sensor inserted in the aortic arch of animals. l-NMMA increased MAP, but did not change HR. This hypertensive response was inhibited by the pre-treatment with prazosin, but accentuated by sotalol. The effect of l-NMMA on MAP was also inhibited by i.v. injections of the ganglionic blocker, hexamethonium. Thus, NO acting on the brain of bullfrog seems to present a hypotensive effect influencing the sympathetic activity dependent on α and β adrenergic receptors in the periphery. © 2013 Elsevier Inc. Department of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900 National Inst. of Science and Technology on Comparative Physiology INCT-Fisiologia Comparada Department of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900
- Published
- 2012