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Start Over Author "Sheumack DD" Journal comparative biochemistry and physiology b comparative biochemistry

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1. The complete amino acid sequence of a post-synaptic neurotoxin isolated from the venom of the Australian death adder snake Acanthophis antarcticus.

Author

Sheumack DD, Spence I, Tyler MI, and Howden ME

Subjects
Amino Acid Sequence, Amino Acids analysis, Animals, Chemical Fractionation, Chymotrypsin, In Vitro Techniques, Mice, Molecular Sequence Data, Neuromuscular Junction drug effects, Peptides analysis, Synaptic Transmission drug effects, Trypsin, Elapid Venoms isolation & purification, Elapid Venoms pharmacology, Neurotoxins isolation & purification
Abstract

1. A lethal neurotoxin (acanthophin d) was isolated from the venom of the Australian death adder snake Acanthophis antarcticus. 2. Acanthophin d consisted of a single polypeptide chain of 74 amino acid residues cross-linked by five disulphide bridges. 3. The results of neurophysiological experiments on murine phrenic nerve hemi-diaphragm preparations were consistent with irreversible post-synaptic blockage of neuromuscular transmission by acanthophin d.

Published
1990
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