1. Lycopene used as Anti-inflammatory Nanodrug for the Treatment of Rheumathoid Arthritis: Animal assay, Pharmacokinetics, ABC Transporter and Tissue Deposition
- Author
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F. S. M. Sinfrônio, Tatiana Almeida Pádua, Ralph Santos-Oliveira, Vivian Meira Moia, Luiciana Magalhaes Rebelo Alencar, Filipe Leal Portilho, Luana Barbosa Correa, Elaine Cruz Rosas, Maria dasGraccedilasMuller de OliveiraHenriques, Angelina Sampson, Eduardo Ricci-Júnior, Frank Alexis, and Surtaj H. Iram
- Subjects
Male ,Antioxidant ,medicine.drug_class ,medicine.medical_treatment ,Anti-Inflammatory Agents ,Arthritis ,02 engineering and technology ,Pharmacology ,01 natural sciences ,Anti-inflammatory ,Arthritis, Rheumatoid ,chemistry.chemical_compound ,Mice ,Structure-Activity Relationship ,Colloid and Surface Chemistry ,Lycopene ,Pharmacokinetics ,In vivo ,0103 physical sciences ,medicine ,Animals ,Physical and Theoretical Chemistry ,010304 chemical physics ,Dose-Response Relationship, Drug ,Chemistry ,Zymosan ,Surfaces and Interfaces ,General Medicine ,021001 nanoscience & nanotechnology ,medicine.disease ,Bioavailability ,Mice, Inbred C57BL ,Disease Models, Animal ,Rheumatoid arthritis ,Nanoparticles ,ATP-Binding Cassette Transporters ,0210 nano-technology ,Biotechnology - Abstract
Lycopene is a carotenoid drug that has demonstrated several properties, including antioxidant and anti-inflammatory activity. The absorption in human body is very low (10–30 % only). In order to increase the bioavailability, lycopene nanoemulsion was formulated and characterized (atomic force microscopy, thermogravimetric analysis dynamic light scattering and differential scanning calorimetry). Also in vitro assay to evaluate the at-binding with MPR1 was performed. Finally, in vivo assay in animals inducted with rheumathoid arthritis were performed. The results showed that the formulated nanolycopene had superior efficacy when compared with the conventional lycopene (not nano-formulated) in inducted animals (rheumatoid arthritis). The results support the use of nanolycopene as an anti-inflammatory agent for rheumatoid arthritis therapy.
- Published
- 2019