1. In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine
- Author
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Chi Wai Kan, Clara Bik-San Lau, Frency S. F. Ng, Patrick C. L. Hui, Ping-Chung Leung, Eric Chun-Wai Wong, Huawen Hu, Xiaowen Wang, Wen Yi Wang, Ben Chan, and Elaine Wat
- Subjects
Drug ,Swine ,Skin Absorption ,Sodium ,media_common.quotation_subject ,Composite number ,chemistry.chemical_element ,Poloxamer ,02 engineering and technology ,In Vitro Techniques ,Pharmacology ,Paeonia ,010402 general chemistry ,01 natural sciences ,Hydrogel, Polyethylene Glycol Dimethacrylate ,Colloid and Surface Chemistry ,Gallic Acid ,medicine ,Animals ,Medicine, Chinese Traditional ,Physical and Theoretical Chemistry ,Chromatography, High Pressure Liquid ,Skin ,Transdermal ,media_common ,Drug Carriers ,Chromatography ,Chemistry ,Temperature ,Surfaces and Interfaces ,General Medicine ,Hydrogen-Ion Concentration ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Carboxymethyl cellulose ,Drug Liberation ,Kinetics ,Permeability (electromagnetism) ,Carboxymethylcellulose Sodium ,Poloxamer 407 ,0210 nano-technology ,Algorithms ,Drugs, Chinese Herbal ,Biotechnology ,medicine.drug - Abstract
For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.
- Published
- 2016
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