1. PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour
- Author
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Gasparini, G., Holdich, R.G., and Kosvintsev, S.R.
- Subjects
- *
DRUG solubility , *DRUG delivery systems , *MEDICAL polymers , *MICROENCAPSULATION , *CONTROLLED release drugs , *PARTICLE size determination , *SURFACE chemistry , *EXCIPIENTS - Abstract
Abstract: Particles for subcutaneous depot use encapsulating a model water-soluble drug have been produced from poly(lactic–glycolic acid) (PLGA) using a membrane emulsification—solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported. During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented. Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades. [Copyright &y& Elsevier]
- Published
- 2010
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