1. Highly-sensitive and anti-interferential electrochemical determination of hazardous metronidazole using w-NiSO4·NiS2 coated ZIF-67-derived cobalt/nitrogen-doped carbon.
- Author
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Pan, Yanan, Chen, Duozhe, Fan, Yang, Zuo, Jiabao, Yang, Qi, Qiu, Fan, Qiu, Lili, Song, Haiou, and Zhang, Shupeng
- Subjects
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METRONIDAZOLE , *POISONS , *ELECTROCHEMICAL sensors , *CARDIOGENIC shock , *NANOSTRUCTURED materials - Abstract
Metronidazole (MNZ) is non-biodegradable and highly soluble in water, it is easy to accumulate in the aquatic environment, which has toxic effects in clinical applications such as causing peripheral neuritis, cardiogenic shock and pseudomembranous colitis. In this paper, Co/NC@w-NiSO 4 ·NiS 2 nanospheres were successfully constructed by coating w-NiSO 4 ·NiS 2 on the surface of ZIF-67 as the growth substrate via hydrothermal method and subsequent calcination for electrochemical detection of metronidazole (MNZ). The nanostructure and composition of the materials were confirmed by SEM, TEM, FT-IR and XPS. The sensitivity of Co/NC@w-NiSO 4 ·NiS 2 sensor for MNZ detection is 1977.14 μA/(mM·cm2); the limit of detection (LOD) is as low as 0.009 μM and the linear range is 1 ∼ 200 and 200 ∼ 1000 μM. Moreover, the modified sensor can resist the interference from many traditional living substances, and has good reproducibility and stability. High catalytic activity requires effective molecular transport and exposure of active sites. The successful construction of Co/NC@w-NiSO 4 ·NiS 2 nanostructure promotes the dispersion of materials and the migration of reactants on the electrode surface, and the w-NiSO 4 ·NiS 2 coating on the irregular particles of ZIF-67-derived cobalt/nitrogen-doped carbon suppressed the stacking of the w-NiSO 4 ·NiS 2 nanosheets to expose more catalytic sites. These factors are conducive to increasing the catalytic activity of the modified sensor for highly sensitive MNZ detection and ensuring the activity of catalyst in multiple catalytic cycles. [Display omitted] • Co/NC@w-NiSO 4 ·NiS 2 composite was synthesized via hydrothermal method and pyrolysis. • The composite suppressed the stacking of nanosheets to expose more catalytic sites. • The sensitivity of electrochemical sensor is 1977.14 μA/(mM·cm2). • The electrochemical sensor was used for MNZ analysis in human blood plasma samples. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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