1. Metal free click chemistry on nucleosides and oligonucleotides
- Author
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Ishwar Singh, Joseph S. Vyle, Caroline Batchelor, and Frances Heaney
- Subjects
chemistry.chemical_classification ,Oxidative degradation ,Chemistry ,Oligonucleotide ,F163 Bio-organic Chemistry ,Triazole ,Alkyne ,Combinatorial chemistry ,Catalysis ,chemistry.chemical_compound ,Metal free ,Click chemistry ,Organic chemistry ,Azide - Abstract
Chemoselective ligation of biologically significant moieties through azide alkyne Click Chemistry has recently received much attention1. The reaction is attractive in that it regioselectively affords stable triazole linked bioconjugated products under mild conditions. However, from the view point of the synthetic oligonucleotide chemist, a significant disadvantage is that the non-thermal reaction requires an in situ generated Cu (I) catalyst. Unwanted Cu (I) mediated chemistry, specifically oxidative degradation etc.
- Published
- 2008
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