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We present three experiments using a sequential binary choice task that explore the relationship between two proposed cognitive control functions: set-shifting and place-keeping (i.e., keeping track of one’s place within a sequential task). The task involves switching from one stimulus-response mapping to another across trials, according to a predefined sequence and in the face of occasional brief interruptions. Response-stimulus interval, interruption length and interrupting task were varied. The robust finding across all experiments was that varying response-stimulus interval led to standard effects attributable to set-shifting, while varying interruption length led to standard effects attributable to place-keeping, but in no cases did the factors interact. We interpret the results as supporting the view that set-shifting and place-keeping are achieved by separable control processes and illustrate this interpretation with a computational model of performance on the task. [ABSTRACT FROM AUTHOR]