1. PEG-asparaginase treatment for acute lymphoblastic leukaemia in children: a network meta-analysis
- Author
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Cecilie Utke Rank, Kjeld Schmiegelow, Bodil Als-Nielsen, Birgitte Klug Albertsen, Mats Heyman, Sofie G Hoejfeldt, and Line Stensig Lynggaard
- Subjects
Oncology ,medicine.medical_specialty ,PEG-asparaginase ,business.industry ,Internal medicine ,Meta-analysis ,medicine ,Lymphoblastic leukaemia ,Pharmacology (medical) ,business - Abstract
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effect of the number of PEG-asparaginase doses on survival and relapse in children and adolescents with acute lymphoblastic leukaemia (ALL). Secondary objectives To assess the association between the number of doses of PEG-asparaginase and asparaginase-associated toxicities (e.g. hypersensitivity, thromboembolism, pancreatitis and osteonecrosis). To undertake a network meta-analysis (NMA) at dose-level in order to generate rankings of the number of doses of PEG-asparaginase used in the treatment for ALL, according to their benefits (survival and relapse) and harms (toxicity).
- Published
- 2021