1. Dexamethasone eluting electrodes for cochlear implantation: Effect on residual hearing
- Author
-
D. Douchement, J Lamblin, Florence Siepmann, Juergen Siepmann, Christophe Vincent, A. Terranti, and J. Salleron
- Subjects
Tone burst ,medicine.medical_specialty ,medicine.medical_treatment ,Audiology ,Dexamethasone ,Speech and Hearing ,Hearing ,Cochlear implant ,Evoked Potentials, Auditory, Brain Stem ,otorhinolaryngologic diseases ,medicine ,Electrode array ,Animals ,Inner ear ,Cochlear implantation ,Glucocorticoids ,business.industry ,Auditory Threshold ,Cochlear Implantation ,Electrodes, Implanted ,medicine.anatomical_structure ,Otorhinolaryngology ,Electrode ,Gerbillinae ,business ,medicine.drug - Abstract
The aim of this study was to compare a cochlear implant electrode array loaded with dexamethasone (DXM) with a conventional passive electrode array for the preservation of residual hearing in gerbils.Thirty Mongolian gerbils (Meriones unguiculatus) were implanted with an eluting electrode loaded with DXM (1 and 10%) on one side and a conventional passive electrode on the other side. Hearing thresholds were determined by tone bursts auditory brainstem responses at 4-6 weeks post-implantation and 1-year post-implantation for older gerbils.After 4-6 weeks post-implantation, residual hearing was statistically more preserved with electrode arrays loaded with DXM, regardless of concentration, for the frequencies 16 000 Hz (P = 0.0008), 4000 Hz (P = 0.0038), 1000 Hz (P = 0.0349), and 500 Hz (P = 0.0030). After 1 year, the difference in favor of the DXM+ electrode array was found statistically significant only for the frequency 16 000 Hz (P = 0.0103) but against it for the frequencies 1000 Hz (P = 0.0368) and 500 Hz (P = 0.0010).Electrode array with prolonged release of DXM improved short-term preservation of residual hearing after implantation for the frequencies 500, 1000, 4000, and 16 000 Hz in gerbils. The long-term results at 1 year confirmed these data for higher frequencies, but must be verified for the lower frequencies of 500 and 1000 Hz.
- Published
- 2014