1. Targeting Neuroinflammation to Treat Alzheimer's Disease
- Author
-
J. M. Sanchez-Caro, Patrick Weydt, S. Jahnert, A. Hoffmann, Teodora Stella Wijasa, Róisín M. McManus, A. Van der Perren, Sergio Castro-Gomez, A. Ardura-Fabregat, Yiyi Yang, Peter-Andreas Löschmann, Kitty Reemst, Antonio Boza-Serrano, Michael T. Heneka, A. Webers, Leonardo Iaccarino, Gary E. Landreth, Géraldine Gelders, T. Dierkes, S. Brioschi, Erik Boddeke, K. Kuhbandner, Agnes Paulus, A. Vautheny, A. Tiberi, Carmen Venegas, Xianyuan Xiang, K. Ceyzériat, Cira Dansokho, Lianne Hoeijmakers, and Niklas Lonnemann
- Subjects
0301 basic medicine ,MILD COGNITIVE IMPAIRMENT ,AMYLOID-BETA-PEPTIDE ,ANTIINFLAMMATORY PREVENTION TRIAL ,INDUCED MICROGLIAL ACTIVATION ,TRAUMATIC BRAIN-INJURY ,metabolism [Amyloid beta-Peptides] ,Inflammation ,Review Article ,Disease ,physiopathology [Alzheimer Disease] ,03 medical and health sciences ,POSITRON-EMISSION-TOMOGRAPHY ,0302 clinical medicine ,Immune system ,immunology [Inflammation] ,Alzheimer Disease ,Heat shock protein ,medicine ,drug therapy [Alzheimer Disease] ,Animals ,Humans ,PERIPHERAL BENZODIAZEPINE-RECEPTOR ,Pharmacology (medical) ,ddc:610 ,Molecular Targeted Therapy ,Neuroinflammation ,Innate immune system ,Amyloid beta-Peptides ,business.industry ,Neurodegeneration ,HERPES-SIMPLEX-VIRUS ,drug therapy [Inflammation] ,RANDOMIZED CONTROLLED-TRIAL ,medicine.disease ,Immunity, Innate ,immunology [Alzheimer Disease] ,immunology [Immunity, Innate] ,ADULT HIPPOCAMPAL NEUROGENESIS ,Psychiatry and Mental health ,030104 developmental biology ,physiopathology [Inflammation] ,Neurology (clinical) ,medicine.symptom ,Alzheimer's disease ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Over the past few decades, research on Alzheimer's disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibrils. Recently, a third disease component, the neuroinflammatory reaction mediated by cerebral innate immune cells, has entered the spotlight, prompted by findings from genetic, pre-clinical, and clinical studies. Various proteins that arise during neurodegeneration, including beta-amyloid, tau, heat shock proteins, and chromogranin, among others, act as danger-associated molecular patterns, that-upon engagement of pattern recognition receptors-induce inflammatory signaling pathways and ultimately lead to the production and release of immune mediators. These may have beneficial effects but ultimately compromise neuronal function and cause cell death. The current review, assembled by participants of the Chiclana Summer School on Neuroinflammation 2016, provides an overview of our current understanding of AD-related immune processes. We describe the principal cellular and molecular players in inflammation as they pertain to AD, examine modifying factors, and discuss potential future therapeutic targets. ispartof: CNS Drugs vol:31 issue:12 pages:1057-1082 ispartof: location:New Zealand status: published
- Published
- 2017
- Full Text
- View/download PDF