Search

En 2021, on comptait environ 5,8 millions de personnes atteintes d'hypertension au Canada (1). Malgre les pharmacotherapies disponibles, l'hypertension est une cause majeure de deces et d'handicap dans le monde [...]

In 2021, about 5.8 million people in Canada were living with hypertension. (1) Despite the availability of pharmacotherapy, hypertension is a leading cause of death and disability globally, and in [...]

L'objectif du projet C-CHANGE (Canadian Cardiovascular Harmonized National Guideline Endeavour), une initiative d'harmonisation des lignes directrices nationales de prevention et de prise en charge des maladies cardiovasculaires, est de faciliter [...]

The goal of the Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) process is to give all Canadian health care providers easy access to a comprehensive and practical set of harmonized [...]

BACKGROUND: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans. METHODS: We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014). Patients in the treatment group received perioperative oral curcumin (2000-mg doses 8 times over 4 d). Patients, health care providers and local research staff were unaware of the treatment assignment. The primary outcomes were median concentrations of 4 biomarkers indicating injury and inflammation (postoperative urine interleukin-18 and perioperative rise in serum creatinine, plasma W-terminal pro-B-type natriuretic peptide and plasma high-sensitivity C-reactive protein). RESULTS: Baseline characteristics were similar in the 2 groups (606 patients overall; median age 76 yr). More than 85% of patients in each group took more than 80% of their scheduled capsules. Neither curcumin nor placebo significantly affected any of the 4 biomarkers (p > 0.05 for all comparisons). Regarding the secondary outcomes, there was a higher risk of acute kidney injury with curcumin than with placebo (17% v. 10%, p = 0.01), but no between-group difference in the median length of hospital stay (5 v. 5 days, p > 0.9) or the risk of clinical events (9% v. 9%, p = 0.9). INTERPRETATION: Curcumin had no beneficial effects when used in elective abdominal aortic aneurysm repair. These findings emphasize the importance of testing turmeric and curcumin before espousing their health benefits, as is currently done in the popular media. Trial registration: ClinicalTrials.gov, no. NCT01225094., Many modern medicines come from plants. (1,2) Turmeric, a plant in the ginger family that is native to South Asia, has been used for centuries as a spice and traditional [...]

The Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) is a nationally endorsed guideline process, targeting primary care health care practitioners. The C-CHANGE guideline is a composite of nine of Canada's [...]

In Canada, the multiple chronic conditions and cardiovascular risk factors of our aging population continue to challenge health care providers and burden health systems. Cardiovascular disease is a major contributor [...]

The debate about appropriate blood pressure targets for patients with hypertension and diabetes is of substantial public health importance because the global burden of diabetes and hypertension is large and [...]

Cardiovascular disease is the most prevalent chronic medical condition in Canada, and evidence-based management of risk factors for cardiovascular disease can reduce morbidity and mortality. (1) However, there are more [...]

New guidelines for the management of chronic kidney disease have been developed by the Canadian Society of Nephrology (Appendix 1 contains the fulltext guidelines; available at www.cmaj.ca/cgi/content/full/179/11/1154/DC1). These guidelines describe [...]

ABSTRACT Background: First Nations people with diabetes mellitus and hypertension are at greater risk of renal and cardiovascular complications than are non-native patients because of barriers to health care services. [...]

The number of people with diabetes is expected to double within a decade. Most people with diabetes have or will develop hypertension, and observational and randomized trial evidence has proven [...]

In our research article, we conclude that the regimen of curcumin we tested exerted no beneficial pharmacodynamic effect on the outcomes we assessed in the setting of elective abdominal aortic [...]