The endocannabinoid system in humans is responsible for the majority of physiological protection processes. The cannabinoid receptors CB1 and CB2 modulate the activity of endocannabinoids, such as anandamide, 2-arachydonoylglycerol, virodhamine and others. Some of the most important functions of the cannabinoid receptors and endogenous ligands are neuronal plasticity and nerve regeneration, nociception and pain modulation, cognitive, mnestic and psychoemotional profile correction, also inflamatory, immune, metabolic and alimentary control, sleep and motricity improvement, as well as inhibitory effects in cancer. [ABSTRACT FROM AUTHOR]