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6 results on '"C., Nicolau"'

1. Factors associated with actively working in the very long-term following acute coronary syndrome

Author

Jose C. Nicolau, Remo H.M. Furtado, Talia F. Dalçóquio, Livia M. Lara, Marcela G. Juliasz, Aline G. Ferrari, Carlos A.K. Nakashima, Andre Franci, Cesar A.C. Pereira, Felipe G. Lima, Roberto R. Giraldez, Rocío Salsoso, Luciano M. Baracioli, and Shaun Goodman

Subjects
Long-Term Post-Hospital Discharge, Return to Work, Acute Coronary Syndrome, Medicine (General), R5-920
Abstract

OBJECTIVES: Returning to work after an episode of acute coronary syndrome (ACS) is challenging for many patients, and has both personal and social impacts. There are limited data regarding the working status in the very long-term after ACS. METHODS: We retrospectively analyzed 1,632 patients who were working prior to hospitalization for ACS in a quaternary hospital and were followed-up for up to 17 years. Adjusted models were developed to analyze the variables independently associated with actively working at the last contact, and a prognostic predictive index for not working at follow-up was developed. RESULTS: The following variables were significantly and independently associated with actively working at the last contact: age>median (hazard-ratio [HR], 0.76, p

Published
2021
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3. The role of invasive therapies in elderly patients with acute myocardial infarction

Author

José C. Nicolau, Pedro A. Lemos, Maurício Wajngarten, Roberto R. Giraldez, Carlos V. Serrano Jr., Eulógio E. Martinez, Luciano M. Baracioli, Roberto Kalil, Fábio B. Jatene, Luis A. Dallan, Luis B. Puig, and Noedir A. Stolf

Subjects
Myocardial infarction, Long-term outcome, Elderly population, Coronary artery bypass surgery, Percutaneous coronary intervention, Medicine (General), R5-920
Abstract

INTRODUCTION: In elderly patients with acute myocardial infarction, very little is known about the role of surgical myocardial revascularization and percutaneous coronary intervention (invasive therapies - IT), especially in the context of long-term outcomes after hospital discharge. METHODS: We analyzed 1588 patients with MI who had been included prospectively in a databank and followed for up to 7.5 years. In this population, 548 patients were >70 years old (elderly group - EG), and 1040 were

Published
2009
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4. Effect of β-Blockers on the Risk of Atrial Fibrillation in Patients with Acute Myocardial Infarction

Author

Antonio Eduardo Pesaro, Alexandre de Matos Soeiro, Jose C. Nicolau, Roberto R. Giraldez, Carlos V. Serrano, and Renata Teixeira Ladeira

Subjects
Male, medicine.medical_specialty, Adrenergic beta-Antagonists, Population, Myocardial Infarction, Acute myocardial infarction, macromolecular substances, Hospital mortality, Arrhythmias, Lower risk, Internal medicine, medicine, Humans, In patient, Hospital Mortality, cardiovascular diseases, Myocardial infarction, Mortality, education, Aged, education.field_of_study, business.industry, Incidence (epidemiology), Atrial fibrillation, General Medicine, Odds ratio, Middle Aged, Clinical Science, medicine.disease, Treatment Outcome, β-blockers, cardiovascular system, Cardiology, Female, Epidemiologic Methods, business
Abstract

INTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in patients treated with β-blockers could at least in part explain the benefits of this drug. OBJECTIVE: To investigate the effect of β-blockers on the incidence of atrial fibrillation in patients with acute myocardial infarction. METHODS: We analyzed 1401 patients with acute myocardial infarction and evaluated the occurrence or absence of atrial fibrillation, the use of oral β-blockers and mortality during the first 24 hours. RESULTS: a) The use of β-blockers was inversely correlated with the presence of atrial fibrillation (ρ = 0.004; OR = 0.54). b) Correlations with mortality were as follows: 31.5% in patients with atrial fibrillation, 9.2% in those without atrial fibrillation (ρ < 0.001; Odds Ratio = 4.52), and 17.5% in patients not treated with β-blockers and 6.7% in those who received the drug (ρ < 0.001; OR = 0.34). c) Adjusted Models: The presence of atrial fibrillation was independently correlated with mortality (OR = 2.48, ρ = 0.002). The use of β-blockers was inversely and independently correlated with mortality (OR = 0.53; ρ = 0.002). The patients who used β-blockers showed a lower risk of atrial fibrillation (OR = 0.59; ρ = 0.029) in the adjusted model. CONCLUSION: The presence of atrial fibrillation and the absence of oral β-blockers increased in-hospital mortality in patients with acute myocardial infarction. Oral β-blockers reduced the incidence of atrial fibrillation, which might be at least partially responsible for the drug’s benefit.

Published
2010
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5. The Role of Invasive Therapies in Elderly Patients with Acute Myocardial Infarction

Author

Luciano Moreira Baracioli, Pedro A. Lemos, L. B. Puig, Noedir Antônio Groppo Stolf, Roberto Kalil, Mauricio Wajngarten, Fábio Biscegli Jatene, Eulógio E. Martinez, Luís Alberto Oliveira Dallan, Roberto R. Giraldez, Jose C. Nicolau, and Carlos V. Serrano

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Population, Myocardial Infarction, Context (language use), Percutaneous coronary intervention, Coronary artery bypass surgery, Sex Factors, Internal medicine, medicine, Humans, Prospective Studies, Myocardial infarction, Angioplasty, Balloon, Coronary, Coronary Artery Bypass, Prospective cohort study, education, Survival rate, Aged, lcsh:R5-920, education.field_of_study, Elderly population, business.industry, Hazard ratio, Age Factors, General Medicine, Clinical Science, medicine.disease, Long-Term Care, Long-term outcome, Survival Rate, Treatment Outcome, Cardiology, Female, lcsh:Medicine (General), business, Follow-Up Studies
Abstract

INTRODUCTION: In elderly patients with acute myocardial infarction, very little is known about the role of surgical myocardial revascularization and percutaneous coronary intervention (invasive therapies - IT), especially in the context of long-term outcomes after hospital discharge. METHODS: We analyzed 1588 patients with MI who had been included prospectively in a databank and followed for up to 7.5 years. In this population, 548 patients were >70 years old (elderly group - EG), and 1040 were

Published
2009
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6. Platelet function, coagulation and fibrinolysis in patients with previous coronary and cerebrovascular ischemic events

Author

Renata de Souza Barreiros, Carlos J.D.G. Barbosa, Andre Franci, Luciano Moreira Baracioli, Flávia Bittar Brito Arantes, Jose C. Nicolau, Tânia Rubia Flores da Rocha, Celia Maria Cassaro Strunz, Remo H.M. Furtado, José Antonio Franchini Ramires, and Roberto Kalil Filho

Subjects
Male, medicine.medical_specialty, Platelet Function Tests, Platelet Aggregation, medicine.medical_treatment, Coronary Disease, Coronary Artery Disease, 030204 cardiovascular system & hematology, Fibrinogen, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Fibrinolysis, D-dimer, medicine, Humans, Prospective Studies, 030212 general & internal medicine, cardiovascular diseases, Stroke, Blood Coagulation, Aged, Blood coagulation test, lcsh:R5-920, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Thromboelastography, Blood pressure, Ischemic Attack, Transient, Case-Control Studies, Cardiology, Female, Original Article, Blood Coagulation Tests, business, lcsh:Medicine (General), medicine.drug
Abstract

OBJECTIVES: Ischemic stroke (IS) or transient ischemic attack (TIA) history is present in 4-17% of patients with coronary artery disease (CAD). This subgroup of patients is at high risk for both ischemic and bleeding events. The aim of this study was to determine the role of platelet aggregability, coagulation and endogenous fibrinolysis in patients with CAD and previous IS or TIA. METHODS: A prospective case-control study that included 140 stable CAD patients divided into two groups: the CASE group (those with a previous IS/TIA, n=70) and the CONTROL group (those without a previous IS/TIA, n=70). Platelet aggregability (VerifyNow Aspirin® and VerifyNow P2Y12®), coagulation (fibrinogen and thromboelastography by Reorox®) and endogenous fibrinolysis (D dimer and plasminogen activator inhibitor-1) were evaluated. RESULTS: Patients in the CASE group presented significantly higher systolic blood pressure levels (135.84±16.09 vs 123.68±16.11, p

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