1. Methicillin‐resistant Staphylococcus aureus carriers are vulnerable to bloodstream infection after living donor liver transplantation
- Author
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Naoki Hasegawa, Go Oshima, Yuko Kitagawa, Yuta Abe, Osamu Itano, Minoru Kitago, Hiroshi Yagi, Kentaro Matsubara, Yaoko Takano, Taizo Hibi, Ken Hoshino, Yusuke Takemura, Masahiro Shinoda, Hideaki Obara, Yohei Yamada, Shutaro Hori, Takuya Minagawa, and Tatsuo Kuroda
- Subjects
Male ,Methicillin-Resistant Staphylococcus aureus ,medicine.medical_specialty ,Bacteremia ,Mupirocin ,medicine.disease_cause ,chemistry.chemical_compound ,Japan ,Risk Factors ,Internal medicine ,Living Donors ,medicine ,Humans ,Aged ,Retrospective Studies ,Cross Infection ,Transplantation ,business.industry ,Incidence ,Mortality rate ,Incidence (epidemiology) ,Micafungin ,Retrospective cohort study ,Sulbactam ,Odds ratio ,Middle Aged ,Staphylococcal Infections ,Prognosis ,bacterial infections and mycoses ,Methicillin-resistant Staphylococcus aureus ,Liver Transplantation ,chemistry ,Carrier State ,Female ,business ,human activities ,Follow-Up Studies ,medicine.drug - Abstract
BACKGROUND Bloodstream infection (BSI) is a life-threatening complication after living donor liver transplantation (LDLT). We aimed to explore the incidence and predisposing factors of BSI at our institution. METHODS We conducted a retrospective cohort analysis on all consecutive adults with BSI within 6 months after LDLT performed between 2005 and 2016. For antimicrobial prophylaxis, ampicillin/sulbactam, cefotaxime, and micafungin were administered. From 2011, methicillin-resistant Staphylococcus aureus (MRSA) carriers were decolonized using mupirocin ointment and chlorhexidine gluconate soap. Risk factors for BSI were identified by uni- and multivariate logistic regression. RESULTS Of a total of 106 LDLTs, 42 recipients (40%) suffered BSI. The BSI group demonstrated significantly higher in-hospital mortality rates compared with the non-BSI group (24% vs. 7%, P = .01). We identified MRSA carrier (odds ratio [OR], 19.1; P
- Published
- 2019
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