1. Covid-19: the renin-angiotensin system imbalance hypothesis.
- Author
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Lanza, Katharina, Perez, Lucas G., Costa, Larissa B., Cordeiro, Thiago M., Palmeira, Vitria A., Ribeiro, Victor T., and Simões e Silva, Ana Cristina
- Subjects
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RENIN-angiotensin system , *COVID-19 , *SARS-CoV-2 , *PATHOLOGY , *ANGIOTENSIN II , *H7N9 Influenza - Abstract
The emergency of SARS-CoV-2 in China started a novel challenge to the scientific community. As the virus turns pandemic, scientists try to map the cellular mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin-angiotensin system (RAS) imbalance to explain clinical, laboratory and imaging findings on disease course. We believe that exaggerated activation of ACE/Angiotensin II (Ang II)/Angiotensin Type 1 (AT1) receptor RAS axis in line with reduction of ACE2/Angiotensin-(1-7)/Mas receptor may exert a pivotal role in the pathogenesis of Covid-19. In this perspective, we discuss potential mechanisms and evidence on this hypothesis. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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