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2. Abnormalities of magnetic resonance imaging of the central nervous system in patients with systemic lupus erythematosus correlate with disease severity

Author

M. T. Peltz, Giuseppe Passiu, Alberto Cauli, Giovanni Sanna, R Pala, A. Mathieu, Montaldo C, P. Garau, and P. Nurchis

Subjects
Adult, Central Nervous System, Male, medicine.medical_specialty, Pathology, Adolescent, Central nervous system, Severity of Illness Index, Asymptomatic, Serology, White matter, Rheumatology, Disease severity, Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, In patient, Aged, medicine.diagnostic_test, business.industry, Brain, Magnetic resonance imaging, General Medicine, Middle Aged, Prognosis, Magnetic Resonance Imaging, medicine.anatomical_structure, Female, medicine.symptom, business
Abstract

Forty randomly selected patients with systemic lupus erythematosus (SLE) were studied by clinical and serologic parameters and magnetic resonance imaging (MRI). Abnormal MRI was found in 15/40 patients (37.5%): all 15 cases showed multiple widespread small-sized areas of increased signal in T2 in the white matter; in one of these patients MRI also displayed a large area with a reduced signal in T1 and an increased signal in T2 involving both the white and the gray matter. Among the 15 patients with abnormal MRI, only 7 had neuropsychiatric symptoms. The presence of MRI changes was highest in patients with organic type symptoms and was associated to the highest disease severity scores. A long-term follow up of asymptomatic patients would be useful to establish whether the application of MRI is appropriate for the assessment of CNS involvement in SLE.

Published
1994

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