1. Associations between dietary antioxidants intake and radiographic knee osteoarthritis
- Author
-
Jie Wei, Tuo Yang, Shu-guang Gao, Yusheng Li, Hui Li, Chao Zeng, and Guanghua Lei
- Subjects
Adult ,Male ,0301 basic medicine ,China ,medicine.medical_specialty ,Knee Joint ,Cross-sectional study ,medicine.medical_treatment ,Ascorbic Acid ,Osteoarthritis ,Severity of Illness Index ,Gastroenterology ,Antioxidants ,Selenium ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,Odds Ratio ,Humans ,Vitamin E ,Medicine ,Aged ,Aged, 80 and over ,030203 arthritis & rheumatology ,Vitamin C ,business.industry ,Confounding ,General Medicine ,Odds ratio ,Middle Aged ,Osteoarthritis, Knee ,medicine.disease ,Ascorbic acid ,Carotenoids ,Radiography ,Cross-Sectional Studies ,Logistic Models ,030104 developmental biology ,Dietary Supplements ,Multivariate Analysis ,Physical therapy ,Female ,business - Abstract
The aim of the study is to examine the cross-sectional associations between dietary antioxidants (carotenoid, vitamin C, E, and selenium) intake and radiographic knee osteoarthritis (OA). A total of 4685 participants were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) grade 2 in at least one leg. A multivariable logistic analysis model was established to test the relationship between dietary antioxidants (carotenoid, vitamin C, E, and selenium) intake and radiographic knee OA with adjustment of a number of potential confounding factors. A significant positive association between dietary vitamin C intake (P value for trend was 0.04 in multivariable adjusted analysis) and radiographic knee OA was observed. The relative odds of radiographic knee OA were increased by 0.39 times in the third quintile (OR 1.39, 95 % CI 1.11-1.73), 0.42 times in the fourth quintile (OR 1.42, 95 % CI 1.13-1.79), and 0.33 times in the fifth quintile (OR 1.33, 95 % CI 1.03-1.71). However, radiographic knee OA was not significantly associated with dietary carotenoid, vitamin E, and selenium. Among dietary antioxidants, dietary vitamin C intake was positively correlated with the prevalence of radiographic knee OA, while no significant association was found between dietary intake of carotenoid, vitamin E, and selenium and the prevalence of radiographic knee OA.
- Published
- 2016