1. Incidence of elevated lipoprotein (a) levels in a large cohort of patients with cardiovascular disease
- Author
-
Dieter Horstkotte, Dennis Hinse, Frank van Buuren, Klaus Peter Mellwig, and Cornelius Knabbe
- Subjects
Male ,Hyperlipoproteinemias ,Epidemiology ,Disease ,030204 cardiovascular system & hematology ,Gastroenterology ,Cohort Studies ,chemistry.chemical_compound ,0302 clinical medicine ,Structural Biology ,Germany ,Medicine ,030212 general & internal medicine ,Lipoprotein (a) ,education.field_of_study ,biology ,Incidence ,Incidence (epidemiology) ,General Medicine ,Lipoprotein(a) ,Middle Aged ,Cardiovascular disease ,Up-Regulation ,Cholesterol ,Cardiovascular Diseases ,Female ,lipids (amino acids, peptides, and proteins) ,biological phenomena, cell phenomena, and immunity ,Cohort study ,medicine.medical_specialty ,Population ,Article ,03 medical and health sciences ,Internal medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,education ,Molecular Biology ,Aged ,Angiology ,business.industry ,Endocrinology ,chemistry ,biology.protein ,Risk stratifcation ,business ,Biomarkers - Abstract
Background Recently it has been demonstrated that elevated lipoprotein (a) (LPA) levels are associated with an increased risk of cardiovascular disease across multiple ethnic groups. However, there is only scanty data about the incidence of elevated LPA levels in different patient cohorts. As a consequence, we aimed to examine whether patients with elevated LPA levels might be seen more often in a cardiovascular center in comparison to the general population. Methods We reviewed LPA concentrations of 52,898 consecutive patients who were admitted to our hospital between January 2004 and December 2014. We subdivided them into different groups according to their LPA levels. Data was compared to available information in medical literature. Results 26.4% of the patients had LPA levels >30 mg/dl which is in line with the data from literature. Mean level of LPA concentration in our study was twice as high in comparison to the general population (25.8% vs. 13.3%). 4.6% had LPA levels >98 mg/dl (general population 30 mg/dl is comparable to the general population but mean levels over all are twice as high and the proportion of patients with LPA levels of >98 mg/dl is extremely higher.
- Published
- 2017