1. Bone mineral content in nephrotic children on long-term, alternate-day prednisone therapy.
- Author
-
Polito C, La Manna A, Todisco N, Cimmaruta E, Sessa G, and Pirozzi M
- Subjects
- Absorptiometry, Photon, Adolescent, Body Height, Bone and Bones chemistry, Bone and Bones drug effects, Calcium administration & dosage, Calcium therapeutic use, Case-Control Studies, Child, Child, Preschool, Drug Administration Schedule, Female, Humans, Hydroxycholecalciferols administration & dosage, Hydroxycholecalciferols therapeutic use, Male, Nephrotic Syndrome metabolism, Prednisone administration & dosage, Bone Density drug effects, Nephrotic Syndrome drug therapy, Prednisone therapeutic use
- Abstract
Bone mineral content (BMC) was measured by single-photon absorptiometry in 24 children with steroid-dependent, minimal-lesion nephrotic syndrome after 1 to 6.3 years of alternate-day prednisone therapy and in a sex- and age-matched control group. Bone mineral content was -0.002 +/- 1.2 standard deviation scores in patients and 0.3 +/- 1.4 in controls (t = 1.17; P = 0.25). No significant relation was found between BMC in patients and the amount of prednisone taken or the duration of therapy. Alternate-day prednisone therapy at doses usually needed to keep children with steroid-dependent nephrotic syndrome under control does not significantly affect BMC.
- Published
- 1995
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