1. Association of Blood Calcidiol Levels and Metabolic Syndrome in Children and Adolescents With Vitamin D Deficiency.
- Author
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Isart, Fernando A., Isart-Infante, Fernando Jose, and Heidel, R. Eric
- Subjects
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VITAMIN D deficiency , *RESEARCH funding , *LOGISTIC regression analysis , *RETROSPECTIVE studies , *MULTIVARIATE analysis , *DESCRIPTIVE statistics , *LONGITUDINAL method , *ODDS ratio , *METABOLIC syndrome , *BLOOD pressure , *CONFIDENCE intervals , *VITAMIN D , *ADOLESCENCE , *CHILDREN - Abstract
This retrospective cohort study aimed to determine whether severe calcidiol deficiency [25-hydroxyvitamin (OH)D <30 nmol/L] improvement has a beneficial effect on cardiometabolic parameters in children and adolescents (5-17 years) with or without metabolic syndrome (MetS). Logistic regression analysis was performed to test for multivariate associations between potential confounders and changes in vitamin D (VD) status from baseline to follow-up care when predicting binary categorical outcomes. Of 562 participants, 146 (26%) had MetS. Individuals with severe VD deficiency (VDD) were more likely to have MetS with elevated blood pressure than those with sufficient (≥75 nmol) VD levels (adjusted odds ratio [AOR], 4.46; 1.08-18.43; p <.05) at follow-up. In the logistic regression model, every unit increase in VD across time decreased the odds of MetS (AOR, 0.98; 95% confidence interval: [0.96, 0.99]; p <.05). Improvement in VD status demonstrated a beneficial metabolic effect in children and adolescents with severe VDD. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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