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Objectives: The aim of this randomized clinical trial was to assess the effect of solvent use during the removal of root canal filling on postoperative pain after retreatment., Materials and Methods: Ninety patients scheduled for root canal retreatment were randomly assigned to one of the following two groups according to the root canal filling removal procedure used: ProTaper retreatment (Dentsply Maillefer, Ballaigues, Switzerland) instruments or ProTaper retreatment instruments in combination with gutta-percha solvent. A single operator performed the retreatments in a single visit. The incidence and intensity of the postoperative pain were rated on a numeric rating scale by patients at 24, 48, and 72 h after retreatment. The analgesic tablet intake number was also recorded. Data were analyzed using Mann‑Whitney U, Wilcoxon, and chi-square tests., Results: For the intensity of postoperative pain, the difference between the two groups was not statistically significant. Moreover, no statistically significant difference was found between the two groups in terms of analgesic medication intake (P > 0.05)., Conclusions: The processes involving the use and non-use of a solvent in the removal of root canal fillings were found to be equivalent in terms of postoperative pain intensity and analgesic intake., Clinical Relevance: Some in vitro studies claimed that the use of a gutta-percha solvent in the removal of root canal fillings tends to reduce postoperative pain since extrusion of debris was significantly less. This randomized clinical trial indicates that the removal of root canal fillings with or without the use of a solvent was associated with equivalent postoperative pain intensity and analgesic intake. This study is registered in the www.ClinicalTrials.gov database with the identifier number NCT03756363.

Objectives: The purpose of this study was to assess the clinical and radiographic outcome of root-end microsurgery using a premixed fast-set calcium silicate putty as root-end filling material in human teeth., Materials and Methods: This study included 50 teeth in 35 patients, whose ages ranged from 16 to 69 years. After clinical and radiographic examination, informed consent was obtained and one resident performed all surgical procedures using an endodontic microsurgical approach. A tricalcium silicate-based putty (TotalFil FS putty, FKG Dentair, La Chaux-de-Fonds, Switzerland) was used as a root-end filling material. Patients were recalled and treated teeth were examined clinically and radiographically at 3 months, 6 months, and 1 year postoperatively. The outcome was determined based on clinical and radiographic results. Radiographic healing was classified into 4 categories: complete, incomplete, uncertain, and unsatisfactory. Analysis of predictors was performed using the Pearson chi-square or Fisher's exact test., Results: At the time of surgery, 3 teeth were diagnosed with cracks and were excluded from the study. The recall rates were 85% at 3 months, 100% at 6 months, and 95% at 1 year. One tooth failed at 3 months, 3 failed at 1 year, with a success rate of 93%. None of the predictors investigated had a significant influence on the outcome of microsurgery., Conclusions: Premixed fast-set tricalcium silicate putty is a suitable root-end filling material for use in endodontic microsurgery., Clinical Relevance: Tricalcium silicate-based cements have shown promising biological properties as a root-end-filling material. Premixed and fast-set formulations achieved high success rates in clinical studies., Trial Registration: Clinicaltrials.gov registration number NCT03733938.